Integrative Neuroscience

Research includes:

  • Addiction
  • Aggresome
  • Alzheimer's Disease
  • Amyloid
  • Amyloid Plaques
  • Amyotrophic Lateral Sclerosis
  • Auditory Neuroscience
  • Axonal Growth
  • Axonal Transport
  • Behavior
  • Behavioral Neuroscience
  • Central Nervous System
  • Dopamine
  • Drug Abuse
  • Feeding Behavior
  • Genetic Engineering
  • Ingestive Behavior
  • Lewy Bodies
  • Mental Illness
  • Mitochondria
  • Molecular Neuropharmacology
  • Molecular Psychiatry
  • Neural Development
  • Neurodegeneration
  • Neurofibrillary Tangles
  • Neurofilament
  • Neuron-glia Interactions
  • Neurons
  • Neuropsychopharmacology
  • Oxidative Stress
  • Parkinson's Disease
  • Peripherin
  • Pharmacology
  • Protein Aggregation
  • Regulatory Behavior
  • Sensory System Neurobiology (emphasis on the auditory and vestibular systems)
  • Substance Abuse
  • Substantia Nigra
  • Superoxide Dismutase
  • Synuclein
  • Tyrosine Hydroxylase

Training Group Mission:

Neuroscience is a truly integrative discipline as evidenced by the fact that faculty in this program are drawn from approximately 10 departments representing 5 schools at Purdue University. Both the breadth and depth of the research programs among the Purdue faculty span the nervous systems of diverse species, e.g. fruit flies, zebra fish, mice, rats, and humans. Further, the research approach among these systems spans the molecular, cellular, physiological, and behavioral levels of analysis. Students enter the program from diverse undergraduate majors, with equally diverse research interests, and consequently receive training across the levels of analysis required to effectively understand the nervous system and its function. One of the special aspects of the Neuroscience Program is that the participating faculty are drawn from departments and schools within Purdue University not typically associated with training in the life sciences. This inherent diversity in the problem areas and technical approaches taken will offer students from other training programs within PULSe this broad perspective in a way that is relevant to their own disciplines and research.


Faculty Membership

Faculty
Research Area

Protein trafficking and membrane transport in relation to the processes of cell polarity establishment and carcinogenic transformation

Central auditory neurophysiology and neuroanatomy at the systems and cellular levels
Systems Neuroscience of Audition, Human Neuroimaging and Electrophysiology, Phenomenological and Biophysical Models of Auditory Computations, Sensorineural Hearing Loss, Auditory Processing Disorders, Autism

Gene x Environment Interactions in Neurological Disease; Metal Neurotoxicity (manganese, methylmercury, copper); Huntington’s Disease, Parkinson’s Disease, Alzheimer’s Disease, Neurodevelopmental disorders

Behavorial Neuroscience
Neurodegeneration, neurotoxicology, Parkinson's disease
Identification of genetic, neurobiological, and environmental factors that contribute to alcohol drinking and the development of alcoholism

Chemical Immunology: Cell specific chemical perturbation of immune microenvironments in cancer, neurological and immunological disorders

Neuronal circuits in visual perception and learning Optogenetics Neurotechnology Autism Alzheimer's Disease Stroke
Genetic and genomic investigation of naturally-occurring canine diseases and traits
Inner ear development using zebrafish and chicken embryo animal models.
Sensory component of the vagus nerve; development and role in regulation of food intake and body weight
Neural network models of human behavior, human-computer interactions, cognitive psychology
Environmental and molecular toxicology, genomics, and cytogenetics
Nanostructures and mesoscopic systems, musical acoustics, computational neuroscience, computational physics
Neural coding in normal and impaired auditory systems
Computational cognitive neuroscience, cognitive psychology, neuroimaging
Molecular pharmacology

Jessica Huber, Ph.D., CCC-SLP, is a Professor in Speech, Language, and Hearing Sciences at Purdue University. The broad aim of her NIH funded research
program is to understand the multiple factors that influence speech production and cognitive change in older adults with and without Parkinson’s disease (PD) and
to translate findings to clinical treatment. Dr. Huber is the inventor of a small wearable device, the SpeechVive device, to treat communication impairments in
people with PD.

Neuropharmacology, cell signaling, macromolecular machines, ion channels, kinases and calcium signaling.

Bionanotechnology and biosensors
Neural and endocrine factors involved in the control of food intake and regulation of energy balance
Auditory physiology
Disease-causing gene network and novel therapies for retinal degeneration
Magnetic resonance imaging, image and signal processing,brain decoding and modeling
Use of optimality models in behavioral ecology; energy regulation and communication in birds and mammals
Neural basis of sensory perception and sensory-guided behavior
Identification and mapping of the neural circuitry controlling feeding and drinking
NeuroEngineering / Cellular Neurobiology

The cellular basis of visual processing in zebrafish

Protein misassembly diseases
Signal transduction and protein Ser/Thr phosphatases
Identification of circuits mediating fear, safety and reward behaviors

Signal processing in auditory brainstem neural circuits Sensory "un-masking" by brainstem circuits Effects of noise-induced hearing loss on neural coding in the central nervous system

Drug Discovery in Cancer and Alzheimer's Disease Using Chemical Biology Tools
Cellular and molecular underlying mechanism of nerve damage and recovery
Regulator of G protein signaling (RGS) proteins regulation by ubiquitin-proteasomal degradation and post-translational, transcriptional and epigenetic mechanisms. RGS protein drug discovery.
Psychoacoustics, auditory perception by normal and hearing impaired listeners

Nervous system development, neuronal growth cone motility and guidance, cell adhesion and migration, cytoskeletal dynamics, signal transduction, ROS signaling, neuronal mechanics, advanced live cell imaging

Development of controls of ingestive behavior in rats
Applications and techniques to enhance clinical usage of functional neuroimaging; cochlear implant signal processing
Activity-dependent metabolic and oxidative stress in neurons and glia; protein engineering; biosensors; live-cell microscopy; Parkinson’s; glioma; TBI
G-protein coupled receptor pharmacology of addiction and neurological disorders
Signaling of G protein-coupled receptors with an emphasis on dopamine receptors and adenylate cyclases

Aging photoreceptors in the eye show characteristic changes in gene expression. Our lab is interested in understanding the mechanisms that drive these changes in gene expression. These studies provide a model for understanding how aging contributes to ocular diseases such as age-related macular degeneration. Our work is funded by the National Eye Institute of the NIH. We are actively seeking new graduate students, so please contact us if you are interested in joining our group.

Specialization: pharmacogenomics, ion channels, electrophysiology, induced pluripotent stem cells (iPSCs), neurological diseases (e.g., chronic pain, epilepsy, and autism)

Theoretical issues in movement coordination and movement timing
Blood-brain barrier and neurotoxicology of Alzheimer's disease and Parkinsonian disorders

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