Maria S. Sepulveda

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Neurotoxicity and thyroid toxicity of per- and polyfluoroalkyl substances (PFAS) on Xenopus and leopard frogs.

Selected Publications:

Relevant Refereed Publications

Tornabene, BJ, MF Chislock, ME Gannon, MS Sepúlveda, and JT Hoverman. (2021) Relative acute toxicity of three per- and polyfluoroalkyl substances on nine species of larval amphibians. Integrated Environmental Assessment and Management. In Press.

Wasel O, Thompson KM, Gao Y, Godfrey AE, Gao J, Mahaptra C, Lee LS, Sepúlveda MS, Freeman JL. (2021). Comparison of zebrafish in vitro and in vivo developmental toxicity assessments of perfluoroalkyl acids (PFAAs). Journal of Toxicology and Environmental Health, Part A. In Press.

Ankley GT, Cureton P, Hoke RA, Houde M, Kumar A, Kurias J, Lanno R, McCarthy C, Newsted J, Salice CJ, Sample BE, Sepúlveda MS, Steevens J, Valsecchi S. (2021) Assessing the ecological risks of per- and polyfluoroalkyl substances: Current state-of-the science and a proposed path forward. Environmental Toxicology and Chemistry. In Press.

Abercrombie, SA, M Iachetta, C de Perre, RW Flynn, MS Sepúlveda, LS Lee, and JT Hoverman. (2021) Sublethal effects of dermal exposure to poly- and perfluoroalkyl substances on post-metamorphic amphibians. Environmental Toxicology and Chemistry. In Press.

Flynn, RW, M Iachetta, C de Perre, LS Lee, MS Sepúlveda, and JT Hoverman. (2021) Chronic per-/polyfluoroalkyl substance exposure under environmentally relevant conditions delays development in northern leopard frog (Rana pipiens) larvae. Environmental Toxicology and Chemistry. In Press.

Flynn RW, Hoskins TD, Iacchetta M, Perre C, Lee LS, Hoverman JT, Sepúlveda MS. (2021) Dietary exposure and accumulation of per- and polyfluoroalkyl substances alters growth and reduces body condition of post-metamorphic salamanders. Science of the Total Environment. In Press.

Foguth, RM, TD Hoskins, GC Clark, M Nelson, RW Flynn, C de Perre, JT Hoverman, LS Lee, MS Sepúlveda, JR Cannon. (2020) Single and mixture per- and polyfluoroalkyl substances accumulate in developing Northern leopard frog brains and produce complex neurotransmission alterations. Neurotoxicology and Teratology 81:106907.

Foguth R, Sepúlveda MS, Cannon J. (2020) Per- and polyfluoroalkyl substances (PFAS) neurotoxicity in sentinel and nontraditional laboratory model systems: potential utility in predicting adverse outcomes in human health. Toxics 8(2), 42.

Abercrombie SA, C de Perre, Y-J Choi, BJ Tornabene, MS Sepúlveda, LS Lee, JT Hoverman. (2019) Larval amphibians rapidly bioaccumulate PFOA and PFOS. Ecotoxicology and Environmental Safety 178:137-145.

Godfrey A, Hooser B, Abdel-moneim A, Sepúlveda MS. (2019) Sex specific endocrine disrupting effects of three halogenated chemicals in Japanese medaka. Journal of Applied Toxicology 39:1215-1223.

Hoover G, K Supratik, S Guffey, J Leszczynski, MS Sepúlveda. (2019) In vitro and in silico modeling of perfluoroalkyl substances mixture toxicity in an amphibian fibroblast cell line. Chemosphere 233:25-33.

Foguth RM, RW Flynn, C De Perre, M Iacchetta, LS Lee, MS Sepúlveda, JR Cannon. (2019) Developmental exposure to perfluorooctane (PFOS) and perfluorooctanoic acid (PFOA) selectively decreases brain dopamine levels in northern leopard frogs. Toxicology and Applied Pharmacology 377:114623.

Flynn RW, MF Chislock, ME Gannon, SJ Bauer, BJ Tornabene, JT Hoverman, MS Sepúlveda. (2019) Lethal and sublethal effects of perfluoroalkyl substance mixtures on larval American bullfrogs (Rana catesbeiana). Chemosphere. In Press.

Hoover GM, Chislock MF, Tornabene BJ, Guffey SC, Choi YJ, De Perre C, Hoverman JT, Lee LS, Sepúlveda MS. (2017). Uptake and depuration of four per/polyfluoroalkyl substances (PFASs) in northern leopard frog Rana pipiens tadpoles. Environmental Science & Technology Letters 4:399-403.

Godfrey A, Abdel-moneim A, Sepúlveda MS. (2017). Acute mixture toxicity of halogenated chemicals and their next generation counterparts on zebrafish embryos. Chemosphere 181:710-712.

Godfrey A, Hooser B, Abdel-moneim A, Sepúlveda MS. (2019) Sex specific endocrine disrupting effects of three halogenated chemicals in Japanese medaka. Journal of Applied Toxicology 39:1215-1223.

Kar S, Sepúlveda MS, Roy K, Leszczynski J. (2017). Endocrine-disrupting activity of per- and polyfluoroalkyl substances: Exploring combined approaches of ligand and structure based modeling. Chemosphere 184:514-523.

Mahapatra CT, Damayanti NP, Guffey SC, Serafin SS, Irudayaraj J, Sepúlveda MS. (2017). Comparative in vitro toxicity assessment of perfluorinated carboxylic acids. Journal of Applied Toxicology 37:699-708.

Leet JK, S Sassman, JJ Amberg, AW Olmstead, LS Lee, GT Ankley, MS Sepúlveda. (2015). Environmental hormones and their impacts on sex differentiation in fathead minnows. Aquatic Toxicology 158:98-107.

Other Refereed Publications

Allmon E, Serafin J, Chen S, Rodgers ML, Griffitt R, Bosker T, De Guise S, Sepúlveda MS. (2021) Effects of polycyclic aromatic hydrocarbons and abiotic stressors on Fundulus grandis cardiac transcriptomics. Science of the Total Environment. In Press.

Coulter D, T Höök, C Mahapatra, S Guffey, MS Sepúlveda. (2015). Fluctuating water temperatures affect development, physiological responses and cause sex reversal in fathead minnows. Environmental Science and Technology 49:1921-1928.

Chen S, JG McKinney, KM Nichols, MS Sepúlveda. (2014). In silico prediction and in vivo validation of Daphnia pulex microRNAs. PLoS ONE 9: e83708.