Maria S. Sepulveda

Maria S. Sepulveda Profile Picture

Associate Professor of Ecotoxicology and Aquatic Animal Health

Contact Info:

Training Group(s):
Computational and Systems Biology
Cancer Biology

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Dr. Sepúlveda's main area of research is ecotoxicology. Over the last 15 years, she has conducted research evaluating the sublethal effects of a wide-range of environmental contaminants on the physiology of numerous terrestrial and aquatic species. Her main area of interest involves studying the potential health effects of environmental contaminants in populations of free-ranging fish and wildlife. Specifically, Dr. Sepúlveda's research has focused on understanding the effects of pollutants on reproduction and early life-stage development. Besides examining whole animal and tissue-level responses, in recent years Dr. Sepúlveda has begun investigating the effects of chemicals at the sub-cellular and molecular levels using 'omic' tools (genomics, proteomics, and metabolomics). Dr. Sepúlveda also studies diseases in fish and wildlife. Her strong background in veterinary medicine has helped her apply many diagnostic tools in the assessment and evaluation of health status in free-ranging fish and wildlife.

Selected Publications:

Sanchez BC, Ralston-Hooper K, Kowalski KA, Inerowiczb HD, Adamec J, Sepúlveda MS. (2009). Liver proteome response of largemouth bass (Micropterus salmoides) exposed to several environmental contaminants: potential insights into biomarker development. Aquatic Toxicology 95:52-59.

Ralston-Hooper K, Hardy J, Hahn L, Ochoa-Acuña HG, Lee LS, Mollenhauer R, Sepúlveda MS. (2009). Acute and chronic toxicity of atrazine and its metabolites deethylatrazine and deisopropylatrazine on aquatic organisms. Ecotoxicology 18:899-905.

Martyniuk CJ, Sanchez BC, Szabo NJ, Denslow ND, Sepúlveda MS. (2009). Contaminant effects on male largemouth bass: brain transcripts with a role in reproduction. Aquatic Toxicology 95:1-9.

Yin-Ming K, Sepúlveda MS, Hua I, Ochoa-Acuña HG, SuttonTM. (2009). Biomagnification and trophic transfer of polybrominated diphenyl ethers (PBDEs) in a food web of Lake Michigan. Ecotoxicology. In Press. DOI 10.1007/s10646-009-0431-1.

Garcia-Reyero N, Kroll KJ, Liu L, Orlando EF, Watanabe KH, Sepúlveda MS, Villeneuve DL, Perkins EJ, Ankley GT, Denslow ND. (2009). Gene expression responses in male fathead minnows exposed to binary mixtures of an estrogen and antiestrogen. BMC Genomics 10:308.

Garcia-Reyero N, Villeneuve DL, Kroll KJ, Liu L, Orlando EF, Watanabe KH, Sepúlveda MS, Ankley GT, Denslow ND. 2009. Expression signatures for a model androgen and antiandrogen in the fathead minnow (Pimephales promelas) ovary. Environmental Science and Technology 43:873-880.

Watanabe KH, Li Z, Kroll KJ, Villeneuve DL, Garcia- Reyero N, Orlando EF, Sepúlveda MS, Collette TW, Ekman DR, Ankley GT, Denslow ND. (2009). Computational model of the hypothalamic-pituitary-gonadal axis in male fathead minnows exposed to 17±-ethinylestradiol and 17²-estradiol. Toxicological Sciences 109:180-192.

Laban G, Nies LF, Turco RF, Bickham JW, Sepúlveda MS. (2009). The effects of silver nanoparticles on development of fathead minnow (Pimephales promelas) embryos. Ecotoxicology. In Press. DOI 10.1007/s10646-009-0404-4.

Yin-Ming K, Sepúlveda MS, Sutton TM, Ochoa-Acuña HG, Muir AM, Miller B, Hua I. (2009). Bioaccumulation and biotransformation of decabromodiphenyl ether in juvenile lake whitefish (Coregonus clupeaformis). Ecotoxicology. In Press. ECTX762R1.

Johns SM, Denslow ND, Kane MD, Watanabe KH, Orlando EF, Sepúlveda MS. (2009). Effects of estrogens and antiestrogens on gene expression of fathead minnow (Pimephales promelas) early life stages. Environmental Toxicology. In Press. 615144-477010

Sepúlveda MS, Stefanavage T, Goforth R. (2009). First record of Polypodium sp. parasitizing eggs from female shovelnose sturgeon from the Wabash River, Indiana. Journal of Aquatic Animal Health. In Press. JAAH:H09-018R.

Amberg JJ, Goforth R, Stefanavage T, Sepúlveda MS. (2009). Sexually dimorphic gene expression in the gonad and liver of shovelnose sturgeon (Scaphirhynchus platorynchus). Journal of Fish Physiology and Biochemistry. In Press. DOI 10.1007/s10695-009-9369-8

Johns SM, Kane MD, Denslow ND, Watanabe KH, Orlando EF, Villeneuve D, Ankley G., Sepúlveda MS. (2009). Characterization of ontogenetic changes in gene expression in the fathead minnow (Pimephales promelas). Environmental Contamination and Toxicology 28:873-880.

Baker S, Sepúlveda MS. (2009). An evaluation of the effects of persistent environmental contaminants on the reproductive success of great blue herons (Ardea herodias) in Indiana. Ecotoxicology 18:271-280.

Sanchez BC, Carter BJ, Hammers HR, Sepulveda MS. (2009). Transcriptional response of hepatic largemouth bass (Micropterus salmoides) mRNA upon exposure to environmental contaminants. Submitted to BMC Genomics.

Rauschenberger HR, Sepúlveda MS, Wiebe JJ, Wiebe JE, Honeyfield DC, TS Gross. (2009). Nutrient and organochlorine pesticide concentrations in American alligator eggs and their associations with decreased clutch viability. Journal of Aquatic Animal Health. In Press. JAAH:H07-051.

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