Interdisciplinary Life Science - PULSe Great research is a matter of choice

Jason Cannon

Jason Cannon Profile Picture

Associate Professor of Toxicology
Ph.D., Toxicology, University of Michigan


Contact Info:

cannon6@purdue.edu
765-494-0794


Training Group(s):
Integrative Neuroscience


Current Research Interests:

We are a neurotoxicology laboratory focused on identifying novel mechanisms of environmentally-induced neurodegeneration. We have primarily focused on Parkinson’s disease, but are also interested in overlapping pathways between other prominent neurological diseases. We aim to use our mechanistic neurotoxicology data to identify exposures that should be reduced and also to test new therapeutic targets. We are particularly interested in pathogenic interactions between genetic factors and environmental insults. Ongoing projects are primarily focused on: 1) the neurotoxicity of heterocyclic amines, which are formed during high temperature meat cooking and; 2) environmentally-induced aberrations in autophagy. The major techniques utilized in my lab are: neurobehavioral analysis, neurochemistry (HPLC w/electrochemical detection) and histopathology/microscopy using a variety of in vitro and in vivo systems.



Selected Publications:

Wise, J. P., Jr., Price, C. G., Amaro, J. A., and Cannon, J. R. (2018). Autophagy Disruptions Associated With Altered Optineurin Expression in Extranigral Regions in a Rotenone Model of Parkinson's Disease. Front Neurosci 12, 289, 10.3389/fnins.2018.00289.

Cruz-Hernandez, A., Agim, Z. S., Montenegro, P. C., McCabe, G. P., Rochet, J. C., and Cannon, J. R. (2018). Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. Neurotoxicology 65, 68-84, 10.1016/j.neuro.2018.01.009.

Agim, Z. S., and Cannon, J. R. (2018). Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure. Toxicology letters 287, 31-41, 10.1016/j.toxlet.2018.01.017.

Sammi, S. R., Agim, Z. S., and Cannon, J. R. (2018). From the Cover: Harmane-Induced Selective Dopaminergic Neurotoxicity in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology 161(2), 335-348, 10.1093/toxsci/kfx223.

Wise, J. P., Jr., and Cannon, J. (2016). From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models. Toxicological sciences : an official journal of the Society of Toxicology 153(2), 372-81, 10.1093/toxsci/kfw133.

Lee, J. W., Tapias, V., Di Maio, R., Greenamyre, J. T., and Cannon, J. R. (2015). Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiology of aging 36(1), 505-18, 10.1016/j.neurobiolaging.2014.07.011.

Full citation list: http://scholar.google.com/citations?user=l3f_ixcAAAAJ&hl=en 

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