Amy Brewster

Amy Brewster Profile Picture

Assistant Professor
Ph.D. University of California-Irvine, 2006

Contact Info:
(765) 494-5075

Training Group(s):
Integrative Neuroscience

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

My general research interests are to study mechanisms that underlie molecular and structural dendritic alterations, seizures, and behavioral deficits in epilepsy.

Selected Publications:

Kanyshkova T, Pawlowski M, Meuth P, Bender R, Brewster AL, Baumann A, Dubé CM, Baram TZ, Pape HC, Budde T. (2009) Postnatal expression patterns of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. J Neurosci. 29(27):8847-8857.

Bealer SL, Little JG, Metcalf CS, Brewster AL, Anderson AE. (2010) Autonomic and Cellular Mechanisms Mediating Detrimental Cardiac Effects of Status Epilepticus. Epilepsy Res. 91(1):66-73.

Sunnen CN, Brewster AL, Lugo JN, Vanegas F, Turcios E, Mukhi S, Parghi D, D'Arcangelo G, Anderson AE. (2011) mTORC1 inhibition prevents epileptogenesis and reverses mossy fiber sprouting in NS-Pten knockout mice. Epilepsia 52(11):2065-2075.

Surges R, Kukley M, Brewster A, Rüschenschmidt C, Schramm J, Baram TZ, Beck H, Dietrich D. (2012) Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy. Biochem. Biophys. Res. Commun. 420(1):156-160.

Lugo JN, Brewster AL, Spencer CM, Anderson AE. (2012) Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learning and Memory 19(5):182-189.

Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C. (2012) Differential dorso-ventral distributions of Kv4.2 and hyperpolarization-activated cyclic adenosine monophosphate gated channel (HCN) proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. J Biol Chem. 287(21):17656-17661.

Brewster AL, Lugo JN, Patil VV, Lee WL, Qian Y, Vanegas F, Anderson AE. (2013) Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. PLOS ONE 8 (3), e57808

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