Adam Kimbrough

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Our laboratory is currently interested in understanding how the brain is changed after substance use or neurodegenerative diseases. We are interested in how addiction forms, and alters the brain, leading to motivation for excessive drug intake. Current projects include: 1) determining critical brain regions involved in alcohol drinking, 2) assessing how oxycodone use alters brain structure and function, 3) modeling polysubstance use of alcohol and oxycodone, and 4) determining the potential for alcohol use to increase the risk of neurodegenerative diseases such as Alzheimer's disease.

Selected Publications:

Kimbrough, A., Lurie, D.J., Collazo, A., Kreifeldt, M., Sidhu, H., Macedo, G.C., D’Esposito, M., Contet, C., George, O. (2020) Brain-wide functional architecture remodeling by alcohol dependence and abstinence. Proceedings of the National Academy of Sciences USA. PMID: 31937658

Kimbrough, A.*, Kononoff, J.*, Simpson, S.*, Kallupi, M., Sedighim, S., Palomino, K., Conlisk, D.,Momper, J.D., de Guglielmo, G., George, O. (2020) Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats. Psychopharmacology. PMID: 32114633

Smith, L.C. and Kimbrough, A. (2020) Leveraging Neural Networks in Preclinical Alcohol Research. Brain Sciences. PMID: 3285739 Simpson, S., Shankar, K., Kimbrough, A., (2020) George, O. The role of Corticotropin Releasing Factor in alcohol and nicotine addiction. Brain Research. PMID: 32330519

Simpson, S., Kimbrough A., Boomhower, B., Mclellan, R., Hughes M., Shankar K., de Guglielmo, G., George, O. (2020) Antibiotic Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal. eNeuro. PMID:32341122

Feature: Research Highlights Lee, C.H., George., O., Kimbrough A. (2020) Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior. Pharmacology, Biochemistry & Behavior. PMID: 32105663

Kononoff, J., Melas, P., de Guglielmo, G., Kallupi, M., Kimbrough, A., Scherma, M., Kandel, D.B., Kandel, E.R., George, O. (2018). Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Scientific Reports. PMID:30224774

Kononoff, J., Kallupi, M., Kimbrough, A., Conlisk, D., de Guglielmo, G., George, O. (2018) Systemic and intra-habenular activation of the orphan G protein-coupled receptor GPR139 decreases compulsive- like alcohol drinking and hyperalgesia in alcohol-dependent rats. eNeuro. PMID:29971251

Feature: Research Highlights Kimbrough, A., Kim, S., Cole, M., Brennan, M. George, O. (2017). Intermittent access to ethanol drinking facilitates the transition to excessive drinking after chronic intermittent ethanol vapor exposure. Alcoholism: Clinical and Experimental Research. PMID:28679148

Articles of Public Interest Feature Kimbrough, A., de Guglielmo, G., Kononoff, J., Kallupi, M., Zorrilla, E.P., George, O. (2017) CRF1- dependent increases in irritability-like behavior during abstinence from chronic intermittent ethanol vapor exposure. Alcoholism: Clinical and Experimental Research. PMID:28833238