Interdisciplinary Life Science - PULSe Great research is a matter of choice

Alexander Chubykin

Alexander Chubykin Profile Picture

Assistant Professor

Contact Info:

Training Group(s):
Integrative Neuroscience

Current Research Interests:

A major challenge in neuroscience is to understand how brain circuits perform computations, affect perception and behaviors. I am interested in elucidating how neuromodulatory systems induce reward-dependent plasticity of the neural circuits involved in visual perception. I use a multi-disciplinary approach: using optogenetics and robotics to map neural circuits in vitro, and extra- and intracellular electrophysiological recordings in vivo. I use the mouse primary visual cortex (V1) as a model system, as it combines the ease of manipulating visual stimulus with accessibility for in vivo recordings in a genetically tractable animal model. This combination of in vitro and in vivo electrophysiology with the optogenetic tools provides an integrated platform to dissect and manipulate specific circuits relevant for visual perception, and study diseases affecting perception and neural circuit function, such as autism.

Selected Publications:

Chubykin AA*, Roach EB*, Bear MF, Hussain Shuler MG. A cholinergic mechanism for reward timing within primary visual cortex. * - Equal contribution. Neuron, 2013 Feb 20;77(4):723–735. 

Osterweil EK, Chuang SC, Chubykin AA, Bianchi R, Krueger DD, Wong RKS, Bear MF. Lovastatin blocks epileptogenesis in a mouse model of Fragile X syndrome. Neuron, 2013 Jan 23;77(2):243-250.   

Chubykin AA. Neurexins and Neuroligins: A Synaptic Code for Neuronal Wiring That Is Implicated in Autism. In: The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance. Edited by M. Hortsch and H. Umemori. Springer New York, 2009:347-365.

Chubykin AA*, Atasoy D*, Etherton MR, Brose N, Kavalali ET, Gibson JR, Sudhof TC. Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2. Neuron. 2007 Jun 21;54(6):919-31. * - Equal contribution.

Boucard AA, Chubykin AA, Comoletti D, Taylor P, Südhof TC. A Splice Code for Trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to a- and ß-Neurexins. Neuron. 2005 Oct 20;48(2):229-236.

Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC. Dissection of Synapse Induction by Neuroligins: Effect of a Neuroligin Mutation Associated with Autism. J. Biol. Chem. 2005 Jun 10;280(23):22365-74. Epub 2005 Mar 29.

Sara Y, Biederer T, Atasoy D, Chubykin A, Mozhayeva MG, Südhof TC, Kavalali ET. Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci. 2005 Jan 5;25(1):260-70.

Comoletti D, Flynn R, Jennings LL, Chubykin A, Matsumura T, Hasegawa H, Südhof TC, Taylor P. Characterization of the Interaction of a Recombinant Soluble Neuroligin-1 with Neurexin-1-beta. J. Biol. Chem. 2003 Dec 12;278(50):50497-505. Epub 2003 Sep 30.

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