Alexander Chubykin

Alexander Chubykin Profile Picture

Assistant Professor
Ph.D., University of Texas Southwestern Medical Center

Contact Info:
(765) 496-0064

Training Group(s):
Computational and Systems Biology
Integrative Neuroscience

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

A major challenge in neuroscience is to understand how brain circuits perform computations, affect perception and behaviors and how these circuits are altered in
diseases such as autism, Alzheimer's Disease and stroke. We use a multi-disciplinary approach: using optogenetics and robotics to map neural circuits in vitro,
electrophysiological recordings and direct neuronal stem cell reprogramming in vivo. We use the mouse visual cortex as a model system, as it combines the ease of
manipulating visual stimulus with accessibility for in vivo recordings in a genetically tractable animal model. This combination of in vitro and in vivo
electrophysiology with the optogenetic and reprogramming tools provides an integrated platform to dissect and manipulate specific circuits relevant for visual
perception, and study diseases affecting perception and neural circuit function, such as autism, Alzheimer's Disease and stroke.

Selected Publications:

Kissinger S.T.*, Pak A.*, Tang Y., Masmanidis S., Chubykin A.A. Oscillatory encoding of visual stimulus familiarity. J. Neurosci. 2018. In Press. * - Equal contribution.

Huang Y, Y. Jiang, Wu Q, Wu X, An X, Chubykin AA, Cheng J-X, Xu X-M and Yang C. Nanoladders Facilitate Directional Axonal Outgrowth and Regeneration. ACS Biomaterials Science & Engineering. February 17, 2018. 2018, 4 (3), pp 1037–1045

Wu Q, Chubykin AA. Application of Automated Imageguided Patch Clamp for the Study of Neurons in Brain Slices. J. Vis. Exp. 2017 Jul 31;(125). doi: 10.3791/56010.

Wu Q, Kolb I, Callahan BM, Su Z, Stoy W, Kodandaramaiah SB, Neve RL, Zeng H, Boyden ES, Forest CR, Chubykin AA. Integration of autopatching with automated pipette and cell detection in vitro. J Neurophysiol. 2016 Oct 1;116(4):1564-1578. doi: 10.1152/jn.00386.2016.

Kaplan ES, Cooke SF, Komorowski RW, Chubykin AA, Thomazeau A, Khibnik LA, Gavornik JP, Bear MF. Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity. Elife. 2016 Mar 4;5. pii: e11450. doi: 10.7554/eLife.11450.

Harrison RR, Kolb I, Kodandaramaiah SB, Chubykin AA, Yang A, Bear MF, Boyden ES, Forest C. Microchip amplifier for in vitro, in vivo, and automated whole-cell patch-clamp recording. J.Neurophysiol. 2015 Feb 15:113(4):1275-1282. doi: 10.1152/jn.00629.2014.

Chubykin AA*, Roach EB*, Bear MF, Hussain Shuler MG. A cholinergic mechanism for reward timing within primary visual cortex. * - Equal contribution. Neuron, 2013 Feb 20;77(4):723–735.

Osterweil EK, Chuang SC, Chubykin AA, Bianchi R, Krueger DD, Wong RKS, Bear MF. Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome. Neuron, 2013 Jan 23;77(2):243-250.

Chubykin AA*, Atasoy D*, Etherton MR, Brose N, Kavalali ET, Gibson JR, Sudhof TC. Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2. Neuron. 2007 Jun 21;54(6):919-31. * - Equal contribution.

Boucard AA, Chubykin AA, Comoletti D, Taylor P, Südhof TC. A Splice Code for Trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins. Neuron. 2005 Oct 20;48(2):229-236.

Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC. Dissection of Synapse Induction by Neuroligins: Effect of a Neuroligin Mutation Associated with Autism. J. Biol. Chem. 2005 Jun 10;280(23):22365-74. Epub 2005 Mar 29.

Sara Y, Biederer T, Atasoy D, Chubykin A, Mozhayeva MG, Südhof TC, Kavalali ET. Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci. 2005 Jan 5;25(1):260-70.

Comoletti D, Flynn R, Jennings LL, Chubykin A, Matsumura T, Hasegawa H, Südhof TC, Taylor P. Characterization of the Interaction of a Recombinant Soluble Neuroligin-1 with Neurexin-1-beta. J. Biol. Chem. 2003 Dec 12;278(50):50497-505. Epub 2003 Sep 30. Q1122.. Brriieeff

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