Wei Zheng

PULSe Contributor - not currently hosting students for laboratory rotations or recruiting students in the laboratory

Current Research Interests:

(1). To explore mechanisms by which lead (Pb) exposure alters beta-amyloid transport by brain barrier systems and affects the homeostasis of beta-amyloid in the central milieu, leading to cerebral amyloid angiopathy (CAA) in Alzheimer’s disease.

(2). To explore the role of copper (Cu) in adult neurogenesis in subventricular zone (SVZ) by exploring the mechanisms by which the choroid plexus regulates Cu homeostasis in brain as it influences the neuronal activity in the SVZ.

(3). To explore mechanisms, biomarkers and chelation therapy of manganese (Mn)-induced Parkinsonian disorder, by using laboratory animal models, human cohorts and noninvasive technical assessment of cumulative Mn in human bones.

Selected Publications:

Find Dr. Zheng's publications Google Scholar.

1Gu HY, Xu YD, Du N, Yu YQ, Zheng W and Du YS (2022). Lead (Pb) induced monocyte chemoattractant protein-1 in the choroid plexus. Biology 2022; 11(2):308. DOI:10.3390/biology11020308.

Adamson SF, Zheng W*, Agim ZS, Du S, Fleming S, Shannahan J, and Cannon J (2021). Systemic copper disorders influence the olfactory function in adult rats: Roles of altered adult neurogenesis and neurochemical imbalance. Biomolecules 11(9):1315. (PMCID: PMC8471899)

Liu LL, Du, D Zheng W* and Zhang YS (2021). Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier in rats. Neurotoxicology 88:44-56. (PMCID: PMC8748412)

Zheng W* and Ghersi-Egea, JF (2020). Brain barrier systems play no small roles in toxicant-induced brain diseases and disorders. Toxicol Sci 175(2):147-148. (PMCID: PMC7253204).

Shen XL, Xia L, Liu L, Jiang W, Shannahan J, Du Y, and Zheng W* (2020). Altered clearance of beta-amyloid from the cerebrospinal fluid following subchronic lead exposure in rats: Roles of RAGE and LRP1 in the choroid plexus. J Trace Elem Med Biol 61: 126520. (PMCID: PMC7541561)

Gu HY, Territo PR, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Chen Z, Zheng W and Du YS (2020). Evaluation of chronic lead effects in the blood brain barrier system by DCE-CT. J Trace Elem Med Biol 62:126648. (PMCID: PMC7655551)

Adamson SF, Shen X, Jiang W, Lai V, Wang X, Shannahan JH, Cannon JR, Chen J, and Zheng W (2018). Subchronic manganese exposure impairs neurogenesis in the adult rat hippocampus. Toxicol Sci 163(2):592-608. (PMCID: PMC5974792)