Aaron Bowman

Title:

Professor, School of Health Sciences

PhD Granting Institution:

Biomedical Sciences, Univ. California San Diego

Contact:

Email Address: bowma117@Purdue.edu
Lab Website Link: https://hhs.purdue.edu/directory/aaron-bowman/

Primary Training Group:

Integrative Neuroscience

Research Areas:

Neurotoxicology, Persistent and Chronic Toxicity, Gene by Environment Interactions, Human Stem Cell Based Models, Genomics, Genetics, Cell Biology

Current Projects:

The lab employs a diverse range of model systems including patient-derived induced pluripotent stem cells (iPSCs), neuronal cultures and mouse models. The lab aims to define mechanisms of neuronal dysfunction and understand the basis of selective neuropathology, by characterizing the molecular function of disease genes and their interaction with environmental toxicants under both normal and pathological conditions. The lab has been applying iPSC technology to neurotoxicity research for 13+ years, and has established protocols to generate iPSC lines and differentiate them down forebrain, striatal and midbrain neural lineages. The lab applies toxicological and functional approaches, in addition to novel high-throughput screening and high-content approaches. The long-term goal is to use a personalized medicine approach to investigate patient-specific toxicant vulnerabilities and develop neuroprotective strategies that mitigate neurological diseases with environmental etiologies.

Importance of Interdisciplinary Research:

The Bowman lab relies on interdisciplinary collaborations to support and bolster the significance of our work. Evidence of this can be seen in the authorship of our publications and principal investigator teams for the funding of the laboratory.