Cheng Bi
Advisor's Name:
Fang Huang
Email Address:
Training Group:
Biomolecular Structure and Biophysics
Research Summary:
Current single-particle tracking (SPT) methods localize and link particle positions across frames, characterizing underlying motion behavior through statistical analyses such as mean square displacement. However, localization imprecision, structured backgrounds, motion blur, and linkage errors are significant challenges that prevent the accurate extraction of the underlying biomolecule’s motion behavior. My research is focused on developing an accurate, end-to-end deep learning approach to address these issues. Our method bypasses the conventional localization process by utilizing features directly extracted from raw camera frames, estimating motion behavior with minimal information loss. Additionally, I am working on applying two-color single-molecule localization microscopy to study the nanoscale molecular organization of two types of Myosin II within the contractile ring during cytokinesis.
Why did you choose to attend PULSe:
This program represents a critical step in my journey toward becoming a researcher capable of integrating knowledge across different fields to advance biological studies. And PULSe offers an excellent opportunity to be co-mentored by two experts in distinctly different areas, immersing me in cross-disciplinary knowledge and deepening my understanding of both biological science and imaging technology development. Collaborating with a diverse research team and engaging in interdisciplinary projects will not only expand my academic network but also refine my leadership skills, laying the foundation for an independent research career.