Jean-Christophe Rochet profile picture

Jean-Christophe Rochet

Director of PIIN and Professor of Medicinal Chemistry and Molecular Pharmacology

Dr. Jean-Christophe (Chris) Rochet is the director of the Purdue Institute for Integrative Neuroscience and Associate Professor in the Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University. He obtained a PhD at the University of Alberta in Biochemistry in 1998 and then worked as a post-doctoral fellow from 1999-2002 studying mechanisms of alpha-synuclein self-assembly in Parkinson’s disease in the laboratory of Dr. Peter Lansbury at Harvard Medical School. Dr. Rochet assumed his position at Purdue University in August of 2002. Dr. Rochet’s research group has a long-standing interest in CNS disorders including Parkinson’s disease. His lab has taken the approach of characterizing gene products involved in aging and neurodegenerative disorders (e.g. alpha-synuclein, DJ-1), with the aim of elucidating mechanisms of neuronal death and dysfunction. His group’s research involves an interdisciplinary approach with methods ranging from biochemical analyses of recombinant proteins to characterization of neurotoxic and neuroprotective mechanisms in cellular and animal models. Dr. Rochet’s studies in models that reproduce key aspects of PD pathobiology have yielded new insights into genetic and chemical suppressors of neurodegeneration.