Purdue Institute for Drug Discovery

Libraries

Chemical Genomics Facility at Purdue

 

Total number of compounds: > 600,000

Diversity-oriented small molecules – 480,000 total compounds

  1. ChemBridge diversity library – contains 73,000 compounds (280 plates)
  2. ChemBridge DIVERSet – contains 80,000 compounds (251 plates)
  3. ChemDiv library – contains 125,000 compounds (360 plates)
  4. Life Chemicals diversity library – contains 50,000 compounds (157 plates)
  5. Life Chemicals Cherry-picked – contains 29,000 compounds (92 plates)
  6. Enamine Discovery Diverse Set 10K – contains 10,000 compounds (32 plates)
  7. Enamine Discovery Diverse Set 50K – contains 50,000 compounds (157 plates)
  8. ChemDiv 2021 library – contains 12,800 compounds (40 plates)
  9. ChemDiv 2022 library – contains 50,158 compounds (157 plates)

Targeted and focused libraries – 109,060 total compounds (CNS-targeting compounds - 49,260)

  1. ChemBridge CNS set – contains 20,000 compounds (63 plates) – 2005
  2. ChemDiv CNS set – contains 16,000 compounds (50 plates) – May 2017
  3. Life Chemicals CNS set – contains 7,100 compounds (23 plate) – Aug. 2020
  4. Enamine CNS set – contains 1,280 compounds (4 plates) – Feb. 2017
  5. OTAVA CNS set – contains 1,280 compounds (4 plates) – Feb. 2017
  6. TimTec CNS set – contains 3,600 compounds (12 plates) – Feb. 2017
  7. ChemBridge kinase set – contains 11,590 compounds (37 plates) – Feb. 2017
  8. ChemBridge Ion channel set – contains 7360 compounds (23 plates) – Feb. 2017
  9. ChemBridge GPCR set – contains 4,330 compounds (14 plates) – Feb. 2017
  10. ChemBridge NHR set – contains 6,720 compounds (20 plates) – Feb. 2017
  11. ChemBridge Macrocycles CNS set – contains 3,000 compounds (10 plates) – Jun. 2024
  12. Life Chemicals PPI library – contains 6080 compounds (19 plate) – Jun. 2024
  13. Enamine PPI PML library – contains 8960 compounds (28 plate) – Jun. 2024
  14. Enamine Covalent Screening (CSL) library – contains 11,760 compounds (37 plate) – Jun. 2024

 Known drugs, bioactives and natural products – 19,688 total compounds

  1. LOPAC1280 – contains 1280 FDA approved drugs (4 plates) – May 2018
  2. Microsource Spectrum – contains 2400 compounds (8 plates) – Aug. 2013
  3. AnalytiCon MEGx – contains 1000 natural products (4 plates) – Aug. 2013
  4. AnalytiCon NATx – contains 5000 semi-synthetic natural products (16 plates) – Aug. 2013
  5. Selleck Chem Express Pick – contains 4208 compounds (14 plates) – Jun. 2018
  6. TargetMol Bioactive Compound Library – contains 5800 compounds (20 plates) – Jul. 2020

 Fragment libraries – 7200 total compounds

  1. ChemBridge general fragment library – contains 4000 compounds (13 plates) – Feb. 2017
  2. Life Chemicals fragment library – contains 1600 compounds (5 plates) – Feb. 2017
  3. Life Chemicals PPI fragment library – contains 1600 compounds (5 plates) – Feb. 2017
  4. Enamine Cys Covalent - contains 4846 compounds (16 plates) – 2021

 Purdue Proprietary Compound Libraries