Purdue Institute for Drug Discovery

Libraries

Chemical Genomics Facility at Purdue


Diversity-oriented small molecules – 430,000 total compounds

  1. ChemBridge diversity library – contains 73,000 compounds (280 plates)
  2. ChemBridge DIVERSet – contains 80,000 compounds (251 plates)
  3. ChemDiv library  – contains 125,000 compounds (360 plates)
  4. Life Chemicals diversity library – contains 50,000 compounds (157 plates)
  5. Life Chemicals Cherry-picked – contains 29,000 compounds (92 plates)
  6. Enamine Discovery Diverse Set 10K – contains 10,000 compounds (32 plates)
  7. Enamine Discovery Diverse Set 50K – contains 50,000 compounds (157 plates)
  8. ChemDiv 2021 library  – contains 12,800 compounds (40 plates)

Targeted and focused libraries – 79,260 total compounds (CNS-targeting compounds - 49,260)

  1. ChemBridge CNS set – contains 20,000 compounds  (63 plates)
  2. ChemDiv CNS set – contains 16,000 compounds (50 plates)
  3. Life Chemicals CNS set – contains 7,100 compounds (23 plate)
  4. Enamine CNS set – contains 1,280 compounds (4 plates)
  5. OTAVA CNS set – contains 1,280 compounds (4 plates)
  6. TimTec CNS set – contains 3,600 compounds (12 plates)
  7. ChemBridge kinase set – contains 11,590 compounds (37 plates)
  8. ChemBridge Ion channel set – contains 7360 compounds (23 plates)
  9. ChemBridge GPCR set – contains 4,330 compounds (14 plates)
  10. ChemBridge NHR set – contains 6,720 compounds (20 plates)

 Known drugs, bioactives and natural products – 19,688 total compounds

  1. LOPAC1280 – contains 1280 FDA approved drugs (4 plates)
  2. Microsource Spectrum – contains 2400 compounds (8 plates)
  3. AnalytiCon MEGx – contains 1000 natural products (4 plates)
  4. NATx – contains 5000 semi-synthetic natural products  (16 plates)
  5. Selleck Chem Express Pick – contains 4208 compounds (14 plates)
  6. Target Mol Bioactive Compound Library – contains 5800 compounds (20 plates)

 Fragment libraries – 7200 total compounds

  1. ChemBridge general fragment library – contains 4000 compounds (13 plates)
  2. Life Chemicals fragment library – contains 1600 compounds (5 plates)
  3. Life Chemicals PPI fragment library – contains 1600 compounds (5 plates)