Computational and Systems Biology

Research includes:

  • Systems Biology
  • Bioinformatics
  • Computational Biology
  • Computational Chemistry
  • Quantitative Biology
  • Synthetic Biology
  • Genomics
  • Quantitative Genetics and Proteomics

Training Group Mission:

The mission of the Computational and Systems Biology (CSB) group is to train a new generation of highly skilled and interdisciplinary graduate students who are competent in multiple disciplines in biology and the quantitative sciences. The objective is that students will be able to navigate between disciplines and be highly proficient scientists operating at the interface of the life sciences and quantitative sciences.


Faculty Membership

Faculty
Research Area

Chemical Immunology: Cell specific chemical perturbation of immune microenvironments in cancer, neurological and immunological disorders

Neuronal circuits in visual perception and learning Optogenetics Neurotechnology Autism Alzheimer's Disease Stroke
Chemical and systems biology as applied to drug discovery; design, synthesis, and evaluation of small molecule modulators of protein interactions; development and application of high content cell analysis screening platforms.
Genetic and genomic investigation of naturally-occurring canine diseases and traits
Environmental and molecular toxicology, genomics, and cytogenetics
Structural basis for RNA function
Regulation of DNA methylation in development and disease
Macromolecular sequences and the evolution, structure and function of molecules; databases and computational tools for functional genomics
Functional genomics and systems biology
method developments and applications of cryo-EM

Our lab focuses on acquiring and utilizing high throughput sequencing data (e.g. RNA-seq, ChIP-seq, ATAC-seq) to develop new computational models and biological assays to study genome regulation and human diseases, in particular immune related disorders and cancer. We are now working on the discovery and modeling of the regulatory circuitry of the non-coding genome which is essential for maintaining normal cellular physiology.

bioinformatics, computational biology
Bionanotechnology and biosensors
Systems biology of host-pathogen interactions; dengue virus; malaria parasites; protein-protein interactions
formulation, drug delivery, cancer theranostics, solid-state organic chemistry, computation and modeling
Disease-causing gene network and novel therapies for retinal degeneration
Computer-assisted drug design
Dietary controls on the gut microbiome, host-microbe and microbe-microbe metabolic exchange, gut inflammation and enteropathogenesis
Functional genomics; Epigenomics; Histone modification; Environmental responses; Systems Biology; Plant Genetics
System-wide Investigation of protein folding, energetics, and ligand binding

Computational systems biology and systems pharmacology focused on within-host dynamics.

Computational chemistry and biological NMR
Currently we are studying flavi viruses (e.g. Zika, dengue, yellow fever,) Common cold viruses, bacterial viruses and many other viruses
Ecology of natural systems, ecotoxicology, animal health
Cell signaling and morphogenesis in the leaf epidermis
Defining the Molecular Basis for p68 (Dbp2) in Gene Expression and Cellular Proliferation
Evolution of eukaryotic chemodiversity using genomics, network biology, and phylogenetics
Cancer biology; Zebrafish cancer Model; Comparative oncogenomics; Evolutionary developmental biology (Evo-Devo)
Bioinformatics and Biologically Related Disciplines (genomics, nutrition, proteomics, statistical genetics)
Protein tyrosine phosphatases (PTPs), structure and function, PTP-mediated cellular signaling mechanisms, roles of PTPs in normal physiology and diseases, chemical biology and drug discovery

Student Membership

Ernest C. Young Hall, Room 170 | 155  S. Grant Street, West Lafayette, IN 47907-2114 | 765-494-2600

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