Computational and Systems Biology

Research includes:

Systems Biology
Bioinformatics
Computational Biology
Computational Chemistry

Quantitative Biology
Synthetic Biology
Genomics
Quantitative Genetics and Proteomics

Training Group Mission:

The mission of the Computational and Systems Biology (CSB) group is to train a new generation of highly skilled and interdisciplinary graduate students who are competent in multiple disciplines in biology and the quantitative sciences. The objective is that students will be able to navigate between disciplines and be highly proficient scientists operating at the interface of the life sciences and quantitative sciences.

Faculty Membership

Faculty

Research Area

Chopra, Gaurav

Interactome based drug discovery: Computational and analytical chemistry techniques to design and verify small molecules drugs and "cells as drugs" for cancer, neurological and immunological disorders.

Davisson, Vincent Jo

Chemical and systems biology as applied to drug discovery; design, synthesis, and evaluation of small molecule modulators of protein interactions; development and application of high content cell analysis screening platforms.

Golden, Barbara

Structural basis for RNA function

Gowher, Humaira

Regulation of DNA methylation in development and disease

Gribskov, Michael

Macromolecular sequences and the evolution, structure and function of molecules; databases and computational tools for functional genomics

Hazbun, Tony

Functional genomics and systems biology

Jiang, Wen

Structure of tailed dsDNA bacteriophages and Flaviviruses; Membrane protein structure by 2-D crystallization; Cryo-EM method development; Large scale computing for cryo-EM image processing

Kazemian, Majid

Our lab focuses on acquiring and utilizing high throughput sequencing data (e.g. RNA-seq, ChIP-seq, ATAC-seq) to develop new computational models and biological assays to study genome regulation and human diseases, in particular immune related disorders and cancer. We are now working on the discovery and modeling of the regulatory circuitry of the non-coding genome which is essential for maintaining normal cellular physiology.

Kihara, Daisuke

Bioinformatics

LaCount, Doug

Systems biology of host-pathogen interactions; dengue virus; malaria parasites; protein-protein interactions

Li, Tonglei

formulation, drug delivery, cancer theranostics, solid-state organic chemistry, computation and modeling

Leung, Yuk Fai

Disease-causing gene network and novel therapies for retinal degeneration

Lill, Markus A.

Computer-assisted drug design

Lindemann, Stephen R

Dietary controls on the gut microbiome, host-microbe and microbe-microbe metabolic exchange, gut inflammation and enteropathogenesis

Liu, Wanqing

Disease Genomics and Personalized Medicine

Li, Ying

Functional genomics; Epigenomics; Histone modification; Environmental responses; Systems Biology; Plant Genetics

Porterfield, Marshall

n/a

Park, Chiwook

System-wide Investigation of protein folding, energetics, and ligand binding

Paschou, Peristera

n/a

Post, Carol B.

Computational chemistry and biological NMR

Sepulveda, Maria S.

Ecology of natural systems, ecotoxicology, animal health

Szymanski, Daniel

Cell signaling and morphogenesis in the leaf epidermis

Tran, Elizabeth J.

Defining the Molecular Basis for p68 (Dbp2) in Gene Expression and Cellular Proliferation

Weake, Vikki

Chromatin modifying complexes in Drosophila development as a model for neurodegenerative disease and cancer

Zhang, Guangjun

Cancer biology; Zebrafish cancer Model; Comparative oncogenomics; Evolutionary developmental biology (Evo-Devo)

Zhang, Min

Bioinformatics and Biologically Related Disciplines (genomics, nutrition, proteomics, statistical genetics)

Zhang, Zhong-Yin

Protein tyrosine phosphatases (PTPs), structure and function, PTP-mediated cellular signaling mechanisms, roles of PTPs in normal physiology and diseases, chemical biology and drug discovery