Interdisciplinary Life Science - PULSe Great research is a matter of choice

Computational and Systems Biology


Research includes:

  • Systems Biology
  • Bioinformatics
  • Computational Biology
  • Computational Chemistry
  • Quantitative Biology
  • Synthetic Biology
  • Genomics
  • Quantitative Genetics and Proteomics

Training Group Mission:

The mission of the Computational and Systems Biology (CSB) group is to train a new generation of highly skilled and interdisciplinary graduate students who are competent in multiple disciplines in biology and the quantitative sciences. The objective is that students will be able to navigate between disciplines and be highly proficient scientists operating at the interface of the life sciences and quantitative sciences.


Faculty Membership

Faculty
Research Area
Interactome based drug discovery: Computational and analytical chemistry techniques to design and verify small molecules drugs and "cells as drugs" for cancer, neurological and immunological disorders.
Chemical and systems biology as applied to drug discovery; design, synthesis, and evaluation of small molecule modulators of protein interactions; development and application of high content cell analysis screening platforms.
Structural basis for RNA function
Regulation of DNA methylation in development and disease
Macromolecular sequences and the evolution, structure and function of molecules; databases and computational tools for functional genomics
Functional genomics and systems biology
Structure of tailed dsDNA bacteriophages and Flaviviruses; Membrane protein structure by 2-D crystallization; Cryo-EM method development; Large scale computing for cryo-EM image processing

Our lab focuses on acquiring and utilizing high throughput sequencing data (e.g. RNA-seq, ChIP-seq, ATAC-seq) to develop new computational models and biological assays to study genome regulation and human diseases, in particular immune related disorders and cancer. We are now working on the discovery and modeling of the regulatory circuitry of the non-coding genome which is essential for maintaining normal cellular physiology.

Bioinformatics
Systems biology of host-pathogen interactions; dengue virus; malaria parasites; protein-protein interactions
formulation, drug delivery, cancer theranostics, solid-state organic chemistry, computation and modeling
Disease-causing gene network and novel therapies for retinal degeneration
Computer-assisted drug design
Dietary controls on the gut microbiome, host-microbe and microbe-microbe metabolic exchange, gut inflammation and enteropathogenesis
Disease Genomics and Personalized Medicine
Functional genomics; Epigenomics; Histone modification; Environmental responses; Systems Biology; Plant Genetics
System-wide Investigation of protein folding, energetics, and ligand binding
Computational chemistry and biological NMR
Ecology of natural systems, ecotoxicology, animal health
Cell signaling and morphogenesis in the leaf epidermis
Defining the Molecular Basis for p68 (Dbp2) in Gene Expression and Cellular Proliferation
Chromatin modifying complexes in Drosophila development as a model for neurodegenerative disease and cancer
Cancer biology; Zebrafish cancer Model; Comparative oncogenomics; Evolutionary developmental biology (Evo-Devo)
Bioinformatics and Biologically Related Disciplines (genomics, nutrition, proteomics, statistical genetics)
Protein tyrosine phosphatases (PTPs), structure and function, PTP-mediated cellular signaling mechanisms, roles of PTPs in normal physiology and diseases, chemical biology and drug discovery

Student Membership

Ernest C. Young Hall, Room 170 | 155  S. Grant Street, West Lafayette, IN 47907-2114 | 765-494-2600

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