Gregory Henderson

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Lipid metabolism plays a critical role in the supply of fuel to various tissues, and it is physiologically important to alter the rate of lipid shuttling between tissues and cellular compartments as energy needs change throughout the day. Improper regulation of lipid metabolism leads to enhanced risk for metabolic and cardiovascular disease. The Henderson Lab studies lipid metabolism at a biochemical level and in vivo, with focus on lifestyle factors such as energy balance, exercise, and diet selection. Specifically, the research group studies responses of free fatty acid mobilization, lipoprotein kinetics, and accumulation of various lipids within tissues such as the liver. The overall goal is to understand how lipid metabolism responds to physiological stressors and healthful lifestyle factors.

Selected Publications:

Koh JH, Johnson ML, Dasari S, Lebrasseur NK, Vuckovic I, Henderson GC, Cooper S, Shulman GI, Lanza IR, Nair KS. TFAM enhances fat oxidation and attenuates high fat diet induced insulin resistance in skeletal muscle. Diabetes 68(8):1552-1564, 2019.

Tuazon MA, Campbell SC, Klein DJ, Shapses S, Anacker KR, Anthony TG, Uzumcu M, Henderson GC. Effects of ovariectomy and exercise training intensity on energy substrate and hepatic lipid metabolism, and spontaneous physical activity in mice. Metabolism: Clinical and Experimental 83:234-244, 2018.

Bloomer SA, Wellen KE, Henderson GC. Sexual dimorphism in the hepatic protein response to a moderate trans fat diet in senescence-accelerated mice. Lipids in Health and Disease 16(1):243, 2017.

Davitt PM, Henderson GC, Walker AJ, Arent SM. Postprandial hormone response after endurance or resistance exercise in obese women. Comparative Exercise Physiology 13(4): 227-235, 2017.

Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS. Combined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age. Journal of Clinical Endocrinology and Metabolism 100(4): 1654-63. 2015.

Johnson ML, Irving BA, Lanza IR, Vendelbo MH, Konopka AR, Robinson MM, Henderson GC, Klaus KA, Morse DM, Heppelmann C, Bergen HR, Dasari S, Schimke JM, Jakaitis DR, Nair KS. Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging. Journal of Gerontology A: Biological Sciences and Medical Sciences 70(11):1386-93, 2015.

Wilson GJ, Lennox BA, She P, Mirek ET, Al Baghdadi RJ, Fusakio ME, Dixon J, Henderson GC, Wek RC, Anthony TG. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. American Journal of Physiology: Endocrinology and Metabolism 308(4): E283-93, 2015.

Henderson GC. Sexual dimorphism in the effects of exercise on metabolism of lipids to support resting metabolism. Frontiers in Endocrinology 2014 Oct 7;5:162.

Tuazon MA, McConnell TR, Wilson GJ, Anthony TG, Henderson GC. Intensity-dependent and sex-specific alterations in hepatic triglyceride metabolism in mice following acute exercise. Journal of Applied Physiology 118: 61-70, 2015.

Henderson GC, Alderman BL. Determinants of resting lipid oxidation in response to a prior bout of endurance exercise. Journal of Applied Physiology 116: 95-103, 2014.

Liou J, Tuazon MA, Burdzy A, Henderson GC. Moderate compared to low dietary intake of trans-fatty acids impairs strength of old and aerobic capacity of young SAMP8 mice in both sexes. Lipids 48: 1135-1143, 2013.

Davitt PM, Arent SM, Tuazon MA, Golem DL, Henderson GC. Postprandial triglyceride and free fatty acid metabolism in obese women after either endurance or resistance exercise. Journal of Applied Physiology 114: 1743-1754, 2013.

Henderson GC. Kinetic measurement techniques in the evaluation of lipid metabolism. Current Drug Discovery Technologies 10: 209-23, 2013.

Sinner DI, Kim JY, Henderson GC, Igal RA. StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. PLoS ONE 7: e39787, 2012.

Soop M, Nehra V, Henderson GC, Boirie Y, Ford GC, Nair KS. Co-ingestion of whey protein and casein in a mixed meal - demonstration of a more sustained anabolic effect of casein. American Journal of Physiology: Endocrinology and Metabolism 303: E152-62, 2012.

Tuazon MA, Henderson GC. Fatty acid profile of skeletal muscle phospholipid is altered in mdx mice and is predictive of disease markers. Metabolism: clinical and experimental 61: 801-811, 2012.

Henderson GC, Tuazon MA. Separation of positional and geometrical fatty acid isomers as 2-nitrophenylhydrazide derivatives by high performance liquid chromatography. Analytical Biochemistry 413: 66-68, 2011.

Jaleel A, Henderson GC, Madden BJ, Klaus KA, Morse DM, Gopala S, Nair KS. Identification of de novo synthesized and relatively older proteins – Accelerated oxidative damage to de novo synthesized ApoA-1 in type 1 diabetes. Diabetes 59: 2366-2374, 2010.