Tony Hazbun

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

The research philosophy of the Hazbun Lab is to approach biological questions from a network perspective and also utilize traditional scientific reductionist approaches to dissect and understand biological phenomena and mechanisms. Our research program uses systemwide approaches in yeast to investigate biological pathways involved in mitosis and cellular homeostasis related to human disease. We also use chemogenomic profiling to identify antifungal targets and characterize fungal gut metabolomics. In addition to these approaches we also use conventional biochemical, genetic and biophysical approaches to validate and interrogate the cellular network nodes and connections. The lab currently has three major areas of research:

• Functional investigation of the N-terminal methylome
• Chemogenomic profiling of small molecules and identification of antifungal targets
• Metabolomics and drug biotransformation by the microbiome with emphasis on the fungal component

Selected Publications:

Thangamani S, Monasky R, Lee JK, Antharam V, HogenEsch H, Hazbun TR, Jin Y, Gu H, Guo GL. Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota. Journal of Fungi. 2021 Dec;7(12):1030.

Chen P, Paschoal Sobreira TJ, Hall MC, Hazbun TR. Discovering the N-terminal methylome by repurposing of proteomic datasets. Journal of Proteome Research. 2021 Aug 12;20(9):4231-47.

Eldesouky HE, Mayhoub A, Hazbun TR, Seleem MN. Reversal of azole resistance in Candida albicans by sulfa antibacterial drugs. Antimicrobial Agents and Chemotherapy. 2018 Mar 1;62(3):e00701-17.

Guinan J, Wang S, Hazbun TR, Yadav H, Thangamani S. Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans. Scientific reports. 2019 Jun 20;9(1):1-1.