Majid Kazemian

Majid Kazemian Profile Picture

Contact Info:

Training Group(s):
Microbiology, Immunology and Infectious Diseases
Biomolecular Structure and Biophysics
Computational and Systems Biology

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

We are interested in studying underlying mechanism of autoimmune diseases such as rheumatoid arthritis, type I diabetes and asthma and infections including hepatitis and Epstein-Barr viruses leading to cancer. Our lab integrates computational and high throughput experimental approaches (e.g. RNA-seq, ChIP-seq, ATAC-seq, Hi-C) in to identify novel pathways, new host-pathogen interactions and regulatory noncoding RNAs (e.g. enhancer RNAs and circular RNAs) that could trigger disease.

Selected Publications:

M. Kolev, E. West, N. Kunz, E. Moseman, M. Balmer, J. Loetscher, S. Dimeloe, E. Rosser, L. Wedderburn, P. Lavender, A. Cope, L. Wang, D. Chauss, N. Moutsopoulos, M. Kaplan, D. McGavern, S. Holland, C. Hess, M. Kazemian, B. Afzali, C. Kemper, Immunity, (2020). 

J. Martinez-Fabregas, S. Wilmes, L. Wang, M. Hafer, E. Pohler, J. Lokau, C. Garbers, A. Cozzani, J. Piehler, M. Kazemian, S. Mitra, I. Moraga-Gonzalez, "Kinetics of cytokine receptor trafficking determine signaling and functional selectivity", eLife, (2019).

S. Chakravorty, B. Yan, C. Wang, L. Wang, J. T. Quaid, C. F. Lin, S. D. Briggs, J. Majumder, D. A. Canaria, D. Chauss, G. Chopra, M. R. Olson, B. Zhao, B. Afzali, M. Kazemian, "Integrated Pan-Cancer Map of EBV-Associated Neoplasms Reveals Functional Host–Virus Interactions", Cancer Research, (2019).

B. Afzali, J. Grönholm, J. Vandrovcova, C. O'Brien, H. Sun, I. Vanderleyden, F.P. Davis, A. Khoder, Y. Zhang, A.N. Hegazy, A.V. Villarino, I.W. Palmer, J. Kaufman, N.R. Watts, M. Kazemian, O. Kamenyeva, J. Keith, A. Sayed, D. Kasperaviciute, M. Mueller, J.D. Hughes, I.J. Fuss, M.F. Sadiyah, K. Montgomery-Recht, J. McElwee, N.P. Restifo, W. Strober, M.A. Linterman, P.T. Wingfield, H.H. Uhlig, R. Roychoudhuri, T.J. Aitman, P. Kelleher, M.J. Lenardo, J.J. O'Shea, N. Cooper, A.DJ. Laurence, BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency, Nature Immunology, (2017).

 EE West, R. Spolski, M. Kazemian, C. Kemper, W. J. Leonard, TSLP acts on neutrophils to drive complement-mediated killing of methicillin-resistant Staphylococcus aureus, Science Immunology, 2016

M. Kazemian, M. Ren, J. Lin, W. Liao, R. Spolski, W. J. Leonard, Comprehensive assembly of novel transcripts from unmapped human RNA-Sequencing data and their association with cancer, Molecular Systems Biology 11 (8), 826, (2015).

M. Kazemian, W.J. Leonard, Possible HPV38 contamination of endometrial cancer RNA-Seq samples in The Cancer Genome Atlas database, J. Virology, doi: 10.1128/JVI.00822-15, (2015).

M. Kazemian, K. Suryamohan, J. Chen, Y. Zhang, Md. A. H. Samee, M. S. Halfon, S. Sinha, Evidence for deep regulatory similarities in early developmental programs across highly diverged insects. Genome Biology and Evolution. 6 (9): 2301-2320. doi: 10.1093/gbe/evu184, (2014).

M. Kazemian, Hannah Pham, M. Brodsky, S. Sinha, Widespread and distinct sequence signatures of combinatorial transcriptional regulation, Nucleic Acids Research, doi: 10.1093/nar/gkt598, (2013).

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