Purdue Institute for Drug Discovery

SHP2 Inhibitors for Autoimmune Diseases

Overview: 

Tyrosine phosphatase SHP2 inhibitors for the treatment of various autoimmune and inflammatory diseases. 

Status: 

Purdue Faculty: 

Dr. Zhong-Yin Zhang

Research Articles: 

Abnormal PTPN11 enchancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation

Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus