
Biomolecular Structure and Biophysics
Research includes:
- Biological NMR Spectroscopy
- Computational Chemistry/Biology
- Electron Microscopy
- Energy Transduction/Electron Transfer
- Enzyme Catalysis
- Membrane Protein Structure
- Metalloprotein Structure
- Protein Dynamics
- Protein Evolution
- Protein Folding
- RNA Structure/Biochemistry
- Signaling Protein Structure
- Virus Structure
- Xray Crystallography
Training Group Mission:
The central role of biomolecular structure and biophysics in life science research provides the rationale for a program in Biomolecular Structure and Biophysics, focusing on structures of key macromolecules and the understanding of their biological roles. The training group includes expertise in a variety of physical and computational approaches used to determine three-dimensional structure, to probe biophysical properties of biomolecules, and to predict structure/function relationships. Areas of strength include X-ray crystallography, NMR spectroscopy, electron microscopy, bioinformatics, computational biology and biophysics, chemical biology, enzymology, and biofluorescence spectroscopy.
Faculty Membership
Synaptic and dendritic integration in vitro and in vivo, sensory integration, two-photon imaging, optogenetics, sub-cellular patch-clamp recordings, nanotechology, bioelectronics
Our lab focuses on acquiring and utilizing high throughput sequencing data (e.g. RNA-seq, ChIP-seq, ATAC-seq) to develop new computational models and biological assays to study genome regulation and human diseases, in particular immune related disorders and cancer. We are now working on the discovery and modeling of the regulatory circuitry of the non-coding genome which is essential for maintaining normal cellular physiology.
Understanding the regulation of phospholipase C enzymes in cardiovascular disease and cancer through macromolecular structure determination and functional assays.
Structural biology, membrane proteins, protein folding, protein transport across membrane, protein import and trafficking, infectious diseases, pathogenic bacteria, multi-drug resistant bacteria, Gram-negative bacterial pathogens
2) Ceramide-1-phosphate and other sphingolipids signaling in cancers.
3) Zika virus and alteration of host cell lipid metabolism.
4) Disovery of new lipid-binding proteins.
- Training Groups
- Prospective Faculty
- Biomolecular Structure and Biophysics
- Biotechnology
- Chromatin and Regulation of Gene Expression
- Chemical Biology
- Computational and Systems Biology
- Integrative Neuroscience
- Membrane Biology
- Microbiology, Immunology and Infectious Diseases
- Molecular Signaling and Cancer Biology
- Plant Biology