Interdisciplinary Life Science - PULSe Great research is a matter of choice

Robert V. Stahelin

Robert V. Stahelin Profile Picture

Retter Professor of Pharmacy


Contact Info:

rstaheli@purdue.edu

TEL: 765-494-4152


Training Group(s):
Immunology and Infectious Diseases
Membrane Biology
Biomolecular Structure and Biophysics


Current Research Interests:

Interdisciplinary research focused on biological membranes has revealed them as signaling and trafficking platforms for processes fundamental to life. Biomembranes harbor receptors, ion channels, lipid domains, lipid signals, and scaffolding complexes, which function to maintain cellular growth, metabolism, and homeostasis. Moreover, abnormalities in lipid metabolism attributed to genetic changes among other causes are often associated with diseases such as cancer, arthritis and diabetes. Pathogens, including viruses, and bacteria, often hijack human components of lipid metabolism and replicate using biological membranes as platforms or utilize lipids to produce energy during the replication cycle. Thus, there is a need to comprehensively understand molecular events occurring within and on membranes as a means of grasping disease etiology and identifying viable targets for drug development.

Selected Publications:

Del Vecchio, K., Frick, C.T., Gc, J.B., Oda, S.I., Gerstman, B.S., Saphire, E.O., Chapagain, P.P., and Stahelin, R.V.* “A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine” (2018) J. Biol. Chem. DOI: 10.1074/jbc.M117.816280

Wijesinghe, K.J., Urata, S., Bhattarai, N., Kooijman, E.E., Gerstman, B.S., Chapagain, P.P. Li, S., and Stahelin, R.V. “Detection of Lipid Induced Structural Changes of the Marburg Virus Matrix protein VP40 Using Hydrogen/Deuterium Exchange Mass Spectrometry” (2017) J. Biol. Chem. 292, 6108-6122.

Wijesinghe, K.J. and Stahelin, R.V. “Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40” (2016) J. Virol., 90, 3074-3085. ​

Shirey, C.M., Ward, K.E., and Stahelin, R.V. “Investigation of the biophysical properties of a fluorescently modified ceramide-1-phosphate” (2016) Chem. Phys. Lipids 200: 32-41.

Johnson, K.A., Taghon, G.J., Scott, J.L, and Stahelin, R.V. “The Ebola Virus matrix protein VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress” (2016) Sci. Rep. 6:19125.

Adu-Gyamfi, E., Johnson, K.A., Fraser, M.E., Scott, J.L., Soni, S.P., Jones, K.R., Digman, M.A., Gratton, E., Tessier, C.R., and Stahelin, R.V. “Host cell plasma membrane phosphatidylserine regulates the assembly and budding of the Ebola virus” (2015) J. Virol. 89, 9440-9453.

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