Angeline Lyon

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

We use biochemistry, biophysics, and cell-based studies to investigate the structure and function of phospholipase C enzymes. These proteins are required for normal cardiovascular function, and are also involved in inflammation and cancer.

Selected Publications:

Structure and regulation of phospholipase Cβ and ε at the membrane. Muralidharan K, Van Camp MM, Lyon AM. Chem Phys Lipids. 2021 Mar;235:105050. doi: 10.1016/j.chemphyslip.2021.105050. PMID: 33422547

Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A. Sieng M, Selvia AF, Garland-Kuntz EE, Hopkins JB, Fisher IJ, Marti AT, Lyon AM. J Biol Chem. 2020 Dec 4;295(49):16562-16571. doi: 10.1074/jbc.RA120.015685. PMID: 32948655

Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements. Rugema NY, Garland-Kuntz EE, Sieng M, Muralidharan K, Van Camp MM, O'Neill H, Mbongo W, Selvia AF, Marti AT, Everly A, McKenzie E, Lyon AM. Commun Biol. 2020 Aug 14;3(1):445. doi: 10.1038/s42003-020-01178-8. PMID: 32796910

Gαq and the Phospholipase Cβ3 X-Y Linker Regulate Adsorption and Activity on Compressed Lipid Monolayers. Hudson BN, Jessup RE, Prahalad KK, Lyon AM. Biochemistry. 2019 Aug 13;58(32):3454-3467. doi: 10.1021/acs.biochem.9b00441.PMID: 31322863