Meredith Ziliak, Purdue University, will present "Examining the middle latency response in the d-galactose model of aging".
Abstract: Age-related hearing loss (ARHL) is the most common sensory disorder in people over 60 years old and is known to result from auditory processing dysfunction induced by metabolic disorder in the central auditory system (CAS). However, despite its prevalence, ARHL and its effects on the CAS have not yet been comprehensively characterized. Possible reasons for this deficit could be the challenges of studying ARHL. First, any damage to structures or processes upstream of the CAS, such as noise exposure to the inner ear, ambiguates any results measured in the CAS. This confounding factor is practically unavoidable when studying naturally aged subjects. Additionally, using naturally aged animal subjects is costly both in time and funds. To mitigate these complications, we have used the d-galactose model of aging which produces comparable metabolic biomarkers of ARHL and other aging disorders in central, but not peripheral auditory structures and processes, allowing us to isolate age-related damage to the CAS in young subjects. In this ongoing study, we have used the d-galactose model alongside a click train variation stimulus to better characterize metrics of ARHL in the CAS. We have focused our analyses on the effects of aging on the middle latency response. Our preliminary results will be discussed, and future directions explored.
Meeting ID: 432 634 0458
