Biological Sciences and PI4D Co-Sponsored Seminar - Nathaniel Landau

April 25, 2018
1:30 PM - 2:30 PM
Creighton Hall 1011


Dr. Nathaniel Landau, Professor, Dept of Microbiology, Joan and Joel Smilow Research Center, New York University Langone Health 

Wednesday, April 25th

1:30PM in CRTN 1011

"Restriction of HIV by SAMHD1: Starving the Beast"

Lentiviruses like HIV need to evade intrinsic host restrictions that prevent their replication.

The collection of restriction factors produced in cells constitutes the innate immune

response to viruses. Lentiviruses encode accessory proteins that serve to counteract specific

restriction factors. SAMHD1 is one such restriction factor that restricts lentivirus replication

in myeloid cells and resting T cells. Lentiviruses such as SIV encode the accessory

protein Vpx which induces the degradation of SAMHD1. The talk will discuss the mechanisms

by which SAMHD1 restricts lentivirus replication and the mechanism by which Vpx

counteracts SAMHD1. The studies have led to a new approach to the development of a therapeutic

vaccine against HIV.

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