Interdisciplinary Life Science - PULSe Great research is a matter of choice

Chemical Biology

Research includes:

  • Biocatalysis
  • Cellular Regulation
  • Drug Delivery
  • Drug Discovery
  • Glycobiology
  • Lipid Biochemistry
  • Metalobiochemistry
  • Molecular Recognition
  • Protein Folding and Assembly
  • Protein Trafficking
  • Receptor Pharmacology

Training Group Mission:

Students who join this training group work with a diverse group of faculty that apply chemical-based approaches to further the understanding of living systems. Fundamental and technical advances in chemistry, biochemistry, and structural and molecular biology over the past several decades have provided unprecedented opportunities to probe living systems at a molecular level. These advances have led to the development of a rapidly growing multidisciplinary field - Chemical Biology. Within the Chemical Biology training group, students apply groundbreaking chemical methodology to the elucidation of essential biological processes. Additionally, students that have identified new biological targets will drive the development of unique chemical entities. All students receive broad training at the interface of chemistry and biology, allowing the student to master the concepts needed for success in this multidisciplinary area of research.

Faculty Membership

Research Area
Protein structure and function; X-ray crystallography; metalloenzymes; biodegradation of PCBs and related compounds
Development of small molecules, peptides and peptidomimetics for drug discovery, bionanotechnology, and cellular delivery of therapeutic agents

Chemical Immunology: Cell specific chemical perturbation of immune microenvironments in cancer, neurological and immunological disorders

Design and synthesis of molecules that interact with enzymes and membrane-bound receptors
Chemical synthesis and biological evaluation of natural products with medicinal importance and novel, diverse and complex small molecule libraries; medicinal chemistry; mechanism of action study.
Functional role deubiquitinating enzymes in cellular pathways implicated in neurodegeneration, such as Alzheimer's disease and Parkinson's disease
Chemical and systems biology as applied to drug discovery; design, synthesis, and evaluation of small molecule modulators of protein interactions; development and application of high content cell analysis screening platforms.
Chromatin Remodeling and Cancer
Use of chemistry as a tool to elucidate biological mechanisms
Synthetic organic, bioorganic and medicinal chemistry
Structural basis for RNA function
Multidrug resistance in human cancer
Molecular biology, cell biology, cancer biology and molecular imaging
Design and synthesis of chemical inhibitors to interrogate epigenetic pathway towards development of new therapeutic agents
Enzyme mechanism; acetic acid bacteria
Organic and bioorganic mass spectrometry
Bionanotechnology and biosensors
bio-organic chemistry, bioconjugate chemistry, in vitro evolution, drug discovery
Computer-assisted drug design
Organic synthesis, bioorganic chemistry and molecular modeling
Epigenetic regulation of transposable elements
DNA Nanotechnology and Its Application
Biological and Biomedical Analysis Using Mass SpectrometryDevelop of Miniature Mass Spectrometry Analytical Systems
Organic Synthesis and biology of anti-cancer agents and GABA-ergic molecules
Protein misassembly diseases
Drug Discovery in Cancer and Alzheimer's Disease Using Chemical Biology Tools
Regulator of G protein signaling (RGS) proteins regulation by ubiquitin-proteasomal degradation and post-translational, transcriptional and epigenetic mechanisms. RGS protein drug discovery.
Biological-inorganic materials interactions
Activity-dependent metabolic and oxidative stress in neurons and glia; protein engineering; biosensors; live-cell microscopy; Parkinson’s; glioma; TBI
1) development of transiently-stable lipid- and polymer-based carrier systems for targeted drug & gene delivery; 2) development of high-throughput methods for detecting membrane protein activity; 3) development of materials and methods for controlled adsorption and templated protein crystallization
Organic synthesis, nanostructured materials science, self-assembly principles to produce exotic materials with physical or biomimetic function
Marine biological materials: biology, biochemistry, chemistry, polymers, and materials engineering
Controlled drug delivery, bio-nanotechnology
Plant endomembrane trafficking; chemical biology
Protein tyrosine phosphatases (PTPs), structure and function, PTP-mediated cellular signaling mechanisms, roles of PTPs in normal physiology and diseases, chemical biology and drug discovery

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