Interdisciplinary Life Science - PULSe Great research is a matter of choice

Emily Dykhuizen

Emily Dykhuizen Profile Picture

Assistant Professor in Medicinal Chemistry and Molecular Pharmacology
Postdoc, Stanford University (Gerald R. Crabtree), 2009-2013
Ph.D., UW-Madison (Laura L. Kiessling), 2002-2008
BA, Reed College, 1997-2001


Contact Info:

edykhui@purdue.edu


Training Group(s):
Chromatin and Regulation of Gene Expression
Chemical Biology
Molecular Signaling and Cancer Biology


Current Research Interests:

Recent cancer genome sequencing studies have uncovered frequent mutations in genes encoding subunits of nuclear protein complexes involved in chromatin remodeling and epigenetic regulation. The Dykhuizen lab is interested in using a combination of chemical and biochemical techniques to uncover the role of chromatin structure in tumor suppression. Uncovering the mechanisms of these complexes will reveal potential therapeutic avenues for cancers that currently have few therapeutic options, such as renal clear cell carcinoma and ovarian clear cell carcinoma. Three areas of research we are currently pursuing include (1) quantitative mass spectrometric analysis of chromatin remodeling complexes, (2) high throughput screening to identify inhibitors of chromatin remodelers, and (3) the elucidation of the function and genome-wide targeting of chromatin binding domains, such as bromodomains, PHD domains and chromodomains.



Selected Publications:

Dykhuizen EC*, Hargreaves DC*, Miller, EL, Cui K, Korshunov A, Kool M, Pfister S, Cho Y-J, Zhao K, Crabtree, GR. (2013) BAF Complexes Facilitate Decatenation by Topoisomerase IIa. Nature 497, 624-627. *These authors contributed equally to this work

Dykhuizen EC, Carmody L, Tolliday N, Crabtree GR, Palmer MAJ. (2012) Screening for Inhibitors of an Essential Chromatin Remodeler in Mouse Embryonic Stem Cells by Monitoring Transcriptional Regulation. Journal of Biomolecular Screening 17, 1221-30.

Dykhuizen EC, Kiessling LL. (2009) Potent Ligands for Prokaryotic UDP-Galactopyranose Mutase that Exploit an Enzyme Subsite. Organic Letters 11, 193-196.

Dykhuizen EC, May JF, Tongpenyai A, Kiessling LL. (2008) Inhibitors of UDP-Galactopyranose Mutase Thwart Mycobacterial Growth. Journal of the American Chemical Society 130, 6706-6707.

Carlson CB, Mowery P, Owen RM, Dykhuizen EC, Kiessling LL (2007) Selective Tumor Cell Targeting Using Low-Affinity Multivalent Interactions. ACS Chemical Biology 2, 119-127.

Stevens SL, Shaw TE, Dykhuizen E, Lessov NS, Hill JK, Wurst W, Stenzel-Poore MP (2003) Reduced Cerebral Injury in CRH-R1 Deficient Mice After Focal Ischemia: A Potential Link to Microglia and Astrocytes That Express CRH-R1. Journal of Cerebral Blood Flow and Metabolism 23, 1151-1159.

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