David H. Thompson
Professor
Colorado State University, Ph.D., Organic Chemistry
davethom@purdue.edu
765-494-0386
Bindley 294
Laboratory of David H. Thompson
Biomolecular Structure and Biophysics
Chemical Biology
Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees
Current Research Interests:
- Design and development of transiently-stable carrier systems for intracellular drug & nucleic acid delivery
- Applications of energy-efficient, analytics-guided continuous synthesis using telescoped flow reactions
- Materials development for protein structure elucidation by cryoEM
Selected Publications:
DRUG & NUCLEIC ACID DELIVERY K. J. Wright, S. Samaddar, V. Badwaik, S.-H. Hyun, K. Glauninger, T. Eom, D. H. Thompson, “Organocatalytic Synthesis and Evaluation of Polycarbonate Pendant Polymer:beta-Cyclodextrin-based Nucleic Acid Delivery Vectors”, Macromolecules 2018 51, 670-678.
R. VerHeul, C. Sweet, D. H. Thompson, “Rapid and Simple Purification of Elastin-like Polypeptides Directly from Whole Cells and Cell Lysates by Organic Solvent Extraction”, Biomaterials Science 2018 6, 863-876.
MATERIALS DEVELOPMENT FOR CRYO-EM C. J. Benjamin, K. J. Wright, S. Bolton, S.-H. Hyun, K. Krynski, M. Grover, G. Yu, F. Guo, T. Kinzer-Ursem, W. Jiang, D. H. Thompson, “Selective Capture of Histidine-tagged Proteins from Cell Lysates Using TEM Grids Modified with NTA-Graphene Oxide”, Scientific Reports 2016 6, 32500.
Md. R. Hoq, F. S. Vago, K. Li, M. Kovaliov, R. J. Nicholas, D. M. Huryn, P. Wipf, W. Jiang, D. H. Thompson, “Affinity Capture with Small Molecule Bait for CryoEM: New Sample Preparation Method Reveals a 3.6Å Double-ring p97 Structure”, Science Advances 2020, in revision.
FLOW CHEMISTRY PUBLICATIONS Z. Jaman, A. Mufti, S. Sah, L. Avramova, D. H. Thompson, “High-throughput Experimentation and Continuous Flow Validation of Suzuki-Miyaura Cross-Coupling Reactions”, Chemistry – A European Journal 2018 24, 9546-9554.
Z. Jaman, T. J. P. Sobreira, A. Mufti, C. R. Ferreira, R. G. Cooks, D. H. Thompson, “On-demand Rapid Synthesis of Lomustine Under Continous Flow Conditions”, Organic Process Research & Development, 2019 23, 334-341.
B. P. Loren, H. S. Ewan, L. Avramova, C. R. Ferreira, T. J. P. Sobreira, K. Yammine, H. Liu, R. G. Cooks, D. H. Thompson, “High Throughput Experimentation Using DESI-MS to Guide Continuous-Flow Synthesis”, Scientific Reports 2019 9, 14745.
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