Interdisciplinary Life Science - PULSe Great research is a matter of choice

Michael Gribskov

Michael Gribskov Profile Picture

Professor of Biological Sciences and Computer Science
Ph.D., 1985, University of Wisconsin, Madison

Contact Info:

Training Group(s):
Biomolecular Structure and Biophysics
Computational and Systems Biology

Current Research Interests:

The sequence, structure and evolution of proteins are intimately intertwined. This is especially apparent for large protein families such as the protein kinases. Genomics and other high-throughput techniques have made a wealth of information describing proteins, their expression and their interactions available. We try to use this information to understand the function, regulation, and origin of protein families suchs as protein kinases, protein phosphatases, membrane transporters, and participants in the ubiquitin-mediated protein degradation cascade.

More broadly, we develop computational methods for finding patterns in sequences an structures that allow us to make inferences, of the kinds discussed above, about the relationships between sequence, structure and function. These methods include elements datamining, machine learning, modeling, and simulation in the context of biological data. My group is interested in applications to protein motifs, DNA signals (transcription factor binding sites) and modules, and RNA structures.

These studies drive our development of computational tools to find and define protein and nucleic acid sequence and structural patterns, the development of electronic data laboratories, and the development of approaches to interoperation of electronic tools and resources.

Selected Publications:

  • Faculty Profile

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