Interdisciplinary Life Science - PULSe Great research is a matter of choice

Chittaranjan Das

Chittaranjan Das Profile Picture

Assistant Professor Chemistry
Ph.D., Indian Institute of Science, 2001


Contact Info:

cdas@purdue.edu
765-494-5478


Training Group(s):
Biomolecular Structure and Biophysics
Chemical Biology


Current Research Interests:

Currently, we are investigating the normal function of the neuronal DUB ubiquitin C-terminal hydrolase L1 (UCHL1)- a PD-associated, neuron-specific protein of unknown physiological function. Our efforts in this direction are aimed at developing cell-permeable small molecule inhibitors of UCHL1 that can be used to probe its function (both normal and disease-associated), determining its binding partners by affinity based purification from whole-cell extracts, and defining the molecular basis of how a naturally occurring variant of this enzyme- in which Ser at the position 18 is substituted by Tyr (called the S18Y polymorph)- provides protection from Parkinson's disease (PD). In addition to UCHL1, we are also conducting structural and mechanistic investigations of other related enzymes thought to be involved in fundamental biochemical processes such as DNA repair, histone modification, and endocytosis of plasma membrane proteins.



Selected Publications:

Das,C., Hoang,Q.Q., Kreinbring,C.A., Luchansky, S.J., Meray,R.K., Ray,S.S., Lansbury,P.T., Ringe,D., Petsko,G.A., "Structural basis of conformational plasticity of the Parkinson's disease- associated ubiquitin hydrolase UCH-L1", Proceedings of the National Academy of Sciences USA 2006, 103, 4675-4680.

Kornilova,A.Y., Bihel,F., Das,C., Wolfe,M.S., "The initial substrate-binding site of gamma-secretase is located on presenilin near the active site", Proceedings of the National Academy of Sciences USA 2005, 102, 3230-3235.

Bihel,F., Das,C., Bowman,M.J., Wolfe,M.S., "Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase", J Med Chem. 2004, 47, 3931-3933.

Esler,W.P., Das,C., Wolfe,M.S., "Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics", Bioorg Med Chem Lett. 2004, 14, 1935-1938.

  • Faculty Profile

Ernest C. Young Hall, Room 170 | 155  S. Grant Street, West Lafayette, IN 47907-2114 | 765-494-2600

© 2017 Purdue University | An equal access/equal opportunity university | Copyright Complaints | Maintained by The Purdue University Graduate School

If you have trouble accessing this page because of a disability, please contact The Purdue University Graduate School.