Wei-Kung Wang, M.D., Sc.D.
Department of Tropical Medicine,
Medical Microbiology and Pharmacology
John A. Burns School of Medicine
University of Hawaii at Manoa
 
 
“Complexity of human antibody response after dengue virus infection "
The four serotypes of dengue virus are the leading cause of arboviral diseases in humans. Despite the first dengue vaccine (dengvaxia from Sanofi Pasteur) has been licensed by several countries since 2016, its overall moderate efficacy in the presence of neutralizing antibodies during the Phase 2b and 3 trials, low efficacy among dengue naïve individuals, and increased risk of hospitalization among young children highlight the need for a better understanding of humoral responses after natural dengue infection. Our recent studies on different human monoclonal antibodies and polyclonal sera will be presented; our findings together with those from other studies have implications to vaccine strategies for a safe and effective dengue vaccine.
 
 
Wednesday, March 29th
1:30 pm, MRGN 121