September 3, 2020
Wearable, portable invention offers options for treating antibiotic-resistant infections, wounds
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WEST LAFAYETTE, Ind. – The rapid increase of life-threatening, antibiotic-resistant infections has resulted in challenging wound complications with limited choices of effective treatments. About 6 million people in the United States are affected by chronic wounds.
Now, a team of innovators from Purdue University has developed a wearable solution that allows a patient to receive treatment without leaving home. The Purdue team’s work is published in the journal Frontiers in Bioengineering and Biotechnology.
A video showing the technology is available at https://youtu.be/UMZpDwYQZJM.
“We created a revolutionary type of treatment to kill the bacteria on the surface of the wound or diabetic ulcer and accelerate the healing process,” said Rahim Rahimi, an assistant professor of materials engineering at Purdue. “We created a low-cost wearable patch and accompanying components to deliver ozone therapy.”
Ozone therapy is a gas phase antimicrobial treatment option that is being used by a growing number of patients in the U.S. In most cases, the ozone treatments require patients to travel to a clinical setting for treatment by trained technicians.
“Our breathable patch is applied to the wound and then connected to a small, battery powered, ozone-generating device,” Rahimi said. “The ozone gas is transported to the skin surface at the wound site and provides a targeted approach for wound healing. Our innovation is small and simple to use for patients at home.”
The creators are looking for partners to continue developing their technology. For more information, contact Patrick Finnerty of OTC at PWFinnerty@prf.org and reference track code 2020-RAHI-69057.
About Purdue Research Foundation Office of Technology Commercialization
The Purdue Research Foundation Office of Technology Commercialization operates one of the most comprehensive technology transfer programs among leading research universities in the U.S. Services provided by this office support the economic development initiatives of Purdue University and benefit the university's academic activities through commercializing, licensing and protecting Purdue intellectual property. The office recently moved into the Convergence Center for Innovation and Collaboration in Discovery Park District, adjacent to the Purdue campus. In fiscal year 2020, the office reported 148 deals finalized with 225 technologies signed, 408 disclosures received and 180 issued U.S. patents. The office is managed by the Purdue Research Foundation, which received the 2019 Innovation and Economic Prosperity Universities Award for Place from the Association of Public and Land-grant Universities. In 2020, IPWatchdog Institute ranked Purdue third nationally in startup creation and in the top 20 for patents. The Purdue Research Foundation is a private, nonprofit foundation created to advance the mission of Purdue University. Contact email@example.com for more information.
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Wearable and Flexible Ozone Generating System for Treatment of Infected Dermal Wounds
Alexander Roth, Ahmed Elkashif, Vidhya Selvamani, Rachel Abigail Stucky, Mohamed N. Seleem, Babak Ziaie and Rahim Rahimi
Wound-associated infections are a significant and rising health concern throughout the world owing to aging population, prevalence of diabetes, and obesity. In addition, the rapid increase of life-threatening antibiotic resistant infections has resulted in challenging wound complications with limited choices of effective therapeutics. Recently, topical ozone therapy has shown to be a promising alternative approach for treatment of non-healing and infected wounds by providing strong antibacterial properties while stimulating the local tissue repair and regeneration. However, utilization of ozone as a treatment for infected wounds has been challenging thus far due to the need for large equipment usable only in contained, clinical settings. This work reports on the development of a portable topical ozone therapy system comprised of a flexible and disposable semipermeable dressing connected to a portable and reusable ozone-generating unit via a flexible tube. The dressing consists of a multilayered structure with gradient porosities to achieve uniform ozone distribution. The effective bactericidal properties of the ozone delivery platform were confirmed with two of the most commonly pathogenic bacteria found in wound infections, Pseudomonas aeruginosa and Staphylococcus epidermidis. Furthermore, cytotoxicity tests with human fibroblasts cells indicated no adverse effects on human cells.