Research Foundation News

May 2, 2019

New digital filter approach aims to improve chemical measurements, provide more accurate information

measurement science A new filter created at Purdue University is aimed at helping drug developers and researchers create more exact measurements early in the drug development stage. (Stock photo) Download image

Technology could help move novel drugs to clinical trials faster

WEST LAFAYETTE, Ind. – Precise measurements are critical to the discovery, development and usage of medications. Major financial and scientific decisions within pharmaceutical companies are informed by the outcomes of chemical and biological analyses. Even slight measurement variations can add risk and uncertainty in these high-stakes decisions.

A Purdue University professor and expert in measurement science has led a team to design a new filter aimed at helping drug developers and researchers create more exact measurements early in the drug development stage, which can ultimately help move a drug to clinical trials faster.

Garth Simpson, a professor of analytical and physical chemistry in Purdue’s College of Science, created the filter as part of his work with the Merck-Purdue Center for Measurement Science. The academic-industrial partnership, which started in 2017, is focused on developing technology to improve drug manufacturing and formulation to support the pharma industry in expediting drug discovery and delivery. According to the Food and Drug Administration, it can take up 10 to 15 years or longer to move a drug from discovery to the public.

The technology is published in the March 25 edition of Analytical Chemistry.

“This center provides real-world test beds for validating emerging technology related to chemical measurements,” Simpson said. “Our latest development is this novel filter design for digital deconvolution that helps us remove timing artifacts arising from the response function of the instrument we are using for data acquisition.”

Simpson said any practical measurement of an event, including those used for drug discovery, is always a combination of the event itself and the response of the measuring instrument. He said most algorithms used to correct for the response function of the instrument require a great deal of knowledge about the instrument itself.

“Our digital filter approach only requires that a user have the data,” Simpson said. “Our filter and algorithm then use non-negative matrix factorization over short sections of data to allow the analysis of data sets that are too large to be characterized by other conventional approaches.”

The filter uses mathematical formulas to analyze and organize the data, which sometimes contains millions of individual data points, into useable sets for researchers and drug developers.

Simpson said the Purdue filter can be used for measurements in microscopy, chromatography and triboluminescence, all of which are used in the early stages of drug development to determine which molecules show the greatest potential to move ahead to clinical trials.

Simpson has worked with the Purdue Office of Technology Commercialization to patent his measurement science technologies. His research team is looking for additional researchers and partners to license the technologies.

Their work aligns with Purdue's Giant Leaps celebration, celebrating the global advancements in health and artificial intelligence as part of Purdue’s 150th anniversary. Those are two of the four themes of the yearlong celebration’s Ideas Festival, designed to showcase Purdue as an intellectual center solving real-world issues.

About Purdue Office of Technology Commercialization

The Purdue Office of Technology Commercialization operates one of the most comprehensive technology transfer programs among leading research universities in the U.S. Services provided by this office support the economic development initiatives of Purdue University and benefit the university's academic activities. The office is managed by the Purdue Research Foundation, which received the 2016 Innovation and Economic Prosperity Universities Award for Innovation from the Association of Public and Land-grant Universities. For more information about funding and investment opportunities in startups based on a Purdue innovation, contact the Purdue Foundry at foundry@prf.org. For more information on licensing a Purdue innovation, contact the Office of Technology Commercialization at otcip@prf.org. The Purdue Research Foundation is a private, nonprofit foundation created to advance the mission of Purdue University.

Writer: Chris Adam, 765-588-3341, cladam@prf.org 

Source:
Garth Simpson, gsimpson@purdue.edu


Abstract

Iterative Non-Negative Matrix Factorization Filter for Blind Deconvolution in Photon/Ion Counting

Scott R. Griffin, John A. Biechele-Speziale, Casey J. Smith, Ximeng You-Dow, Julia K. White, Si-Wei Zhang, Julie Novak, Zhen Liu and Garth J. Simpson

A digital filter based on non-negative matrix 9 factorization (NMF) enables blind deconvolution of temporal 10 information from large data sets, simultaneously recovering 11 both photon arrival times and the instrument impulse 12 response function (IRF). In general, the measured digital 13 signals produced by modern analytical instrumentation are 14 convolved by the corresponding IRFs, which can complicate quantitative analyses. Common examples include photon counting 15 (PC), chromatography, super resolution imaging, fluorescence imaging, and mass spectrometry. Scintillation counting, in 16 particular, provides a signal-to-noise advantage in measurements of low intensity signals, but has a limited dynamic range due to 17 pulse overlap. This limitation can complicate the interpretation of data by masking temporal and amplitude information on the 18 underlying detected signal. Typical methods for deconvolution of the photon events require advanced knowledge of the IRF, 19 which is not generally trivial to obtain. In this work, a sliding window approach was developed to perform NMF one pixel at a 20 time on short segments of large (e.g., 25 million point) data sets. Using random initial guesses for the IRF, the NMF filter 21 simultaneously recovered both the deconvolved photon arrival times and the IRF. Applying the NMF filter to the analysis of 22 triboluminescence (TL) data traces of active pharmaceutical ingredients enabled discrimination between different hypothesized 23 physical origins of the signal.


 


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