In Print: ‘Solid-State Materials in Pharmaceutical Chemistry: Properties, Characterization and Applications’

Publication title

Solid-State Materials in Pharmaceutical Chemistry: Properties, Characterization and Applications

Purdue author

Stephen Byrn

Authors

Stephen Byrn

George Zografi

Xiaoming (Sean) Chen

Publisher

Wiley

Publication date

October 2025

About the book (from the publisher)

“Solid-State Materials in Pharmaceutical Chemistry” provides readers with a comprehensive and up-to-date resource for understanding and controlling the solid-state properties of pharmaceutical materials, enabling the development of safe and effective medicines including small molecule compounds, peptides, proteins and nucleotides. This new edition covers the significant transformations in the landscape of pharmaceutical research, development and manufacturing since the previous edition was published, presenting both novel challenges and unprecedented opportunities.

New chapters in this edition cover physical and chemical properties of RNA therapeutics, a frontier to many lifesaving medicines and vaccines including COVID vaccines, and final stage drug substance manufacturing and control, addressing challenges in API process development including impurity purging, chiral separation, final form preparation, particle size reduction and nitrosamine control. Readers will also find other updated topics including bulk and surface properties of solids, lipid nanoparticles, applications of pharmaceutical solvates in impurity purging and final form preparation, pharmaceutical cocrystal engineering to enable chiral separation, the emerging technique of microcrystal electron diffraction in solid form characterization, poor wettability of APIs, oral delivery of peptides such as semaglutide, injectable drug-device combination products, and N-nitrosamine control in drug product.

This book is the fourth in Byrn’s series on the solid-state chemistry of drugs, a series whose first volume helped open the field.

About the Purdue author

Stephen Byrn is the Charles B. Jordan Professor of Medicinal Chemistry in the Department of Industrial and Molecular Pharmaceuticals. His research interests focus on solid-state formulation and stability of small molecules, regulatory science, and sustainable medicines in Africa. Byrn has regularly taught in Tanzania, where he worked with a good manufacturing practice-level pharmaceutical facility to teach manufacturing under strict quality control.

About the In Print series

To celebrate our faculty’s excellence in scholarship, Purdue Today’s weekly book series highlights faculty expertise across diverse subjects and disciplines. Find out more about the Purdue University Books Initiative and how to suggest a book for the In Print series on the Office of the Provost website.