Jonathan Shannahan

Jonathan Shannahan Profile Picture

Associate Professor of Toxicology
Ph.D., Toxicology, University of North Carolina Chapel Hill

Contact Info:

Training Group(s):

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

The primary focus of my research group is the mechanistic investigation of nanomaterial-biological interactions and their influence on the applications of nanotechnology. Current research projects include 1) nanomaterial-biomolecule interactions in susceptible subpopulations existing with underlying disease states, 2) immune responses to metal and emerging two-dimensional nanomaterials, 3) cardiopulmonary and immune toxicity assessment of environmental and occupational nanomaterial exposures.  Overall the goal of our research is to understand nanomaterial biological interactions and responses in order to maximize the potential benefits of nanotechnology while insuring that possible adverse health effects are avoided.

Selected Publications:

Shannahan J., Fritz K., Raghavendra A., Podila R., and Brown J. Disease-induced disparities in formation of the nanoparticle-biocorona and the toxicological consequences. Tox. Sci. 2016

Mallineni S., Shannahan J., Raghavendra A., Rao A., Brown J., and Podila R. Biomolecular interactions and biological responses of emerging two-dimensional materials and aromatic amino acid complexes. ACS Appl. Mater Interfaces 2016

Shannahan J., Podila R., and Brown, J.M. A hyperspectral and toxicological analysis of protein corona impact on silver nanoparticle properties, intracellular modifications and macrophage activation. Inter. J. Nanomedicine. 2015

Shannahan J., Sowrirajan H., Persaud I., Podila R., and Brown J.  Impact of Silver and Iron Nanoparticle Exposure on Cholesterol Uptake by Macrophage. J. of Nanomaterials. 2015

Aldossari, A.,* Shannahan, J.,* Podila, R., and Brown, J. (*Authors contributed equally). Influence of physicochemical properties of silver nanoparticles on mast cell activation and degranulation. In Vitro Tox. 2015

Shannahan, J., Podila, R., Aldossari, A., Emerson, A., Powell, B., Ke, P., Rao, A., and Brown, J. (2014). Formation of a protein corona on silver nanoparticles mediates cellular toxicity via scavenger receptors. Tox. Sci. 2014

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