Hyunyoung Jeong
Professor, Department of Industrial and Physical Pharmacy
Ph.D., Pharmacokinetics, University of Illinois at Chicago, 2004
youngjeong@purdue.edu
765-496-0852
RHPH 302B
https://openwetware.org/wiki/Jeong_lab
Microbiology, Immunology and Infectious Diseases
Biotechnology
Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees
Current Research Interests:
Intestines harbor trillions of microbes that have evolved in the milieu of a diverse diet-derived small molecules. Gut microbiome (the collection of genetic materials harbored by the gut microbes) contains thousands of distinct genes with an enormous capacity to catalyze chemical reactions. Their functions, however, remains largely unknown. Jeong and Lee lab has been investigating the gut microbiota as (1) a drug-metabolizing organ and (2) a modulator of host response to drugs. Based on the expertise of Dr Jeong (a pharmacologist) and Dr Lee (a microbiologist), we identify and characterize the microbial factors involved in drug metabolism as well as host-microbe interaction that leads to altered drug efficacy and toxicity.Selected Publications:
Cho S, Won K-J, Yang X, Leone V, Hubert N, Chang EB, Chung E, Park J-S, Lee H, Jeong H. Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity. bioRxiv
Guo Y, Lee H, Jeong H. Gut microbiota in reductive drug metabolism. Progress in Molecular Biology and Translational Science. 2020 171;61-93
Guo Y, Crnkovic CM, Won K-J, Yang X, Lee JR, Orjala J, Lee H, Jeong H. Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites. Drug Metab Disp. 2019;47(3):194-202
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