Rong Huang

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Our lab applies a multidisciplinary approach to 1.) Elucidate the mechanisms and functions of epigenetic modifications including methylation and acetylation; 2.) Rational design and synthesize selective and potent inhibitors for methyltransferases and acetyltransferases; 3.) Develop novel therapeutic agents for cancer and other diseases through targeting epigenetic pathways.

Selected Publications:

Iyamu ID, Vilseck J, Yadav R, Noinaj N, Huang R. (2022) Exploring unconventional SAM analogs to build cell-potent bisubstrate inhibitors for Nicotinamide N‐methyltransferase. Angewandte Chemie International Edition. e202114813.

Ho Y and Huang R. (2022) Effects of oncohistone mutations and PTM crosstalk on the N-terminal acetylation activities of NatD. ACS Chemical Biology. Jan 19. PMID: 35044762. https://pubs.acs.org/doi/full/10.1021/acschembio.1c00840

Chen D, Meng Y, Yu D, Noinaj N, Chen X., Huang R. (2021) Chemoproteomic study uncovers HemK2/KMT9 as a new target for NTMT1 bisubstrate inhibitors. ACS Chemical Biology. 16, 1234-1242. PMID: 34192867; PMCID: PMC8286339. pubs.acs.org/doi/pdf/10.1021/acschembio.1c00279

Deng Y, Deng S, Ho Y, Gardner SM, Huang Z, Marmorstein R, Huang R. (2021) Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D. Journal of Medicinal Chemistry. 64, 8263-8271. PMID: 34110812. pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00141

Al-Hamashi AA, Chen D, Deng Y, Dong G, Huang R. (2021) Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 4/5. Acta Pharmaceutica Sinica B. 11(9), 2709-2718.​www.sciencedirect.com/science/article/pii/S2211383520307656 

Chen D, Dong C, Dong G, Srinivasan K, Min J, Noinaj N, Huang R. (2020) Probing the plasticity in the active site of protein N-terminal methyltransferase 1 using bisubstrate analogs. Journal of Medicinal Chemistry. 63, 8419-8431. PMID: 32605369. PMCID: PMC7429357. https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00770