Rong Huang

Rong Huang Profile Picture

Associate Professor Department of Medicinal Chemistry & Molecular Pharmacology

Contact Info:  

Training Group(s):
Chemical Biology

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Huang lab applies a multidisciplinary approach encompassing the fields of biochemistry, organic and peptide synthesis, chemoproteomics, and cell biology to 1) understand the recognition, mechanism, and function of protein methylation and acetylation; 2) design and synthesize selective and potent inhibitors including new small molecules, peptidomimetics, and peptide conjugates to manipulate and probe the epigenetic pathways; 3) develop novel therapeutic agents for cancer and other diseases through targeting epigenetic pathway

Please see: for detailed information

Selected Publications:

Kronfol MM, Dozmorov MG, Huang R, Slattum PW and McClay JL (2017) The role of epigenomics in personalized medicine. Expert Review of Precision Medicine and Drug Development. 2(1), 33-45. 

Khalil EM, Mackie BD, Mao Y, and Huang R. (2016) Methyltransferases: Key Regulators in Cardiovascular Development and Disease. Annals of Vascular Medicine and Research. 3(2): 1032. Invited Review 

Zhang G, Huang R. (2016) Facile Synthesis of SAM-Peptide Conjugates through Alkyl Linkers Targeting Protein N-terminal Methyltransferase 1. RSC Advance, 6, 6768-6771. 
Cheng D, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R*, and Jin M*. (2015) Structural basis for the substrate recognition by the human N-terminal methyltransferase 1. Gene & Development, 29 (22), 2343-2348. PMID: 26543161. PMCID:PMC4691889 (* co-corresponding  authors) 

Richardson SL, Mao Y, Zhang G, Hanjra P, Peterson DL, Huang R. (2015) Mechanistic studies of protein N-terminal RCC1 methyltransferase 1. Journal of Biological Chemistry, 290 (18), 11601-11610. PMID: 25771539. PMCID:PMC4416863 

Richardson SL, Hanjra P, Zhang G, Mackie BD, Peterson DL, Huang R. (2015) A Direct, ratiometric, and quantitative MALDI-MS assay for protein methyltransferases and acetyltransferases. Analytical Biochemistry: Methods in the Biological Sciences, 478, 59-64. PMID: 25778392. PMCID: PMC4855292. 

Zhang G, Richardson SL, Mao Y, Huang R. (2015) Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors. Organic & Biomolecular Chemistry. 13, 4149-4154. PMID: 25712161. PMCID: PMC4857722. 

Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA Jr, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA. (2014) A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chemical Biology.9(6), 1284-93. PMID:24707965. PMCID: PMC4076021. 

Huang R, Oh H, Arrendale A, Martin VA, Galan J, Workman EJ, Stout JR, Walczak CE, Tao WA, Borch RF, Geahlen RL. (2013) Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK. Biochemical Pharmacology86(5):597-611. PMID:23830822. PMCID: PMC3755495. 

Marian C, Huang R, Borch RF. (2011) Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold. Tetrahedron, 67(52), 10216-10221. PMID:22199405. PMCID: PMC3244727. 

Blair LP, Avaritt NL, Huang R, Cole PA, Taverna SD, Tackett AJ. (2011) MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity. Epigenetics, 6(4), 490-499. PMID:21273814. PMCID: PMC3230537. 

Huang R, Holbert MA, Tarrant MK, Benitski S, Colquhoun DR, Dancy BM, Dancy BC, Hwang Y, Tang Y, Meeth K, Marmorstein R, Cole RN, Khochbin S, Cole PA. (2010) Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. Journal of American Chemical Society, 132(29), 9986-9987. PMID:20608637. PMCID: PMC2912447.  

Huang R, Martinez-Ferrando I, Cole PA. (2010) Enhanced interrogation: emerging strategies for cell signaling inhibition. Nature Structural and Molecular Biology, 17(6), 646-649. PMID:20520657. PMCID: PMC3160762.

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