SERDP amphibian research
‘Forever chemicals’ and amphibians
- PFAS accumulate rapidly in amphibian larvae (i.e. steady-state levels reached within 48 h)
- Aquatic PFAS exposure can affect larval development, growth, body condition, and susceptibility to infection
- Toxicity of simple PFAS mixtures (i.e. PFOS + PFOA) appears to be mostly additive, but there remains potential for synergistic interactions depending on the biological endpoints and specific PFAS examined
- Combined aquatic and sediment PFAS exposure can negatively affect larval development at concentrations found at PFAS-impacted sites
- Dermal PFAS exposure in terrestrial life stages leads to bioaccumulation and can affect growth
- Dietary PFAS exposure in adult salamanders resulted in biomagnification (PFOS), altered growth, and reduced body condition
Abercrombie, SA, M Iachetta, C de Perre, RW Flynn, MS Sepúlveda, LS Lee, and JT Hoverman. 2020. Sublethal effects of dermal exposure to poly- and perfluoroalkyl substances on post-metamorphic amphibians. Environmental Toxicology and Chemistry.
Flynn, RW, M Iachetta, C de Perre, LS Lee, MS Sepúlveda, and JT Hoverman. 2020. Chronic exposure to PFAS-spiked sediment delays development in Northern leopard frog (Rana pipiens) larvae. Environmental Toxicology and Chemistry.
Brown, SR, Flynn, and JT Hoverman. 2020. Perfluoroalkyl substances increase susceptibility of northern leopard frog tadpoles to trematode infection. Environmental Toxicology and Chemistry.
Foguth, RM, TD. Hoskin, GC Clark, M Nelson, RW Flynn, C de Perre, JT Hoverman, LS Lee, MS Sepúlveda, and JR Cannon. 2020. Single and mixture per- and polyfluoroalkyl substances accumulate in developing Northern leopard frog brains and produce complex neurotransmission alterations. Neurotoxicology and Teratology.
Flynn, RW, MF Chislock, ME Gannon, S. Bauer, BJ Tornabene, JT Hoverman, and MS Sepúlveda. 2019. Lethal and sublethal effects of perfluoroalkyl substance mixtures on larval American bullfrogs (Rana catesbeiana). Chemosphere. 236:124350
Abercrombie, SA, C de Perre, YJ Choi, BJ Tornabene, MS Sepúlveda, LS Lee, and JT Hoverman. 2019. Larval amphibians rapidly bioaccumulate poly- and perfluoroalkyl substances. Ecotoxicology and Environmental Safety. 178:137-145.