Faculty Associates

Daniel M. Hirai

Contact Information
Email: dhirai@purdue.edu
Office: LAMB 201C Map
Phone: (765)-494-7113
Fax: (765)-496-1239
Homepage: Homepage
Assistant Professor, Department of Health and Kinesiology

PubMed Listing
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PhD Kansas State University Physiology 2012

Research Interests

Exercise intolerance in heart failure patients, pharmacological and non-pharmacological interventions to improve skeletal muscle microvascular hemodynamics and oxygenation.

Teaching Interests

Exercise physiology, skeletal muscle, oxygen transport


2022 - American Heart Association (AHA) Innovative Project Award
2022 - Ralph W. and Grace M. Showalter Research Trust, Office of the Executive Vice President for Research and Partnerships, Purdue University
2021 - Research Renewal Award, College of Health and Human Sciences, Purdue University
2020 - Laboratory and University Core Facility Research Equipment Program, Office of the Executive Vice President for Research and Partnerships, Purdue University
2020 - College of Health and Human Sciences (HHS) PRF Summer Faculty Grant, Purdue University

Selected Publications

Smith JR, Hirai DM, Copp SW, Ferguson SK, Holdsworth CT, Hageman KS, Poole DC, Musch TI. Effect of exercise training on respiratory muscle blood flow in heart failure rats during submaximal exercise. Respir Physiol Neurobiol; 2021; 292: 103710.

Hirai DM, Tabuchi A, Craig JC, Colburn TD, Musch TI, Poole DC. Regulation of capillary hemodynamics by KATP channels in resting skeletal muscle. Physiol Rep 2021; 9(8):e14803.

Ferguson SK, Woessner MN, Holmes MJ, Belbis MD, Carlstrm M, Weitzberg E, Allen JD, Hirai DM. Effects of inorganic nitrate supplementation on cardiovascular function and exercise tolerance in heart failure. J Appl Physiol 2021; 130(4):914-922.

Monroe JC, Song Q, Emery MS, Hirai DM, Motaganahalli RL, Roseguini BT. Acute effects of leg heat therapy on walking performance and cardiovascular and inflammatory responses to exercise in patients with peripheral artery disease. Physiol Rep 2021; 8(24):e14650.

Hirai DM, Belbis MD, Holmes MJ, Calvo N, Ferguson SK. The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies. J Appl Physiol 2020; 129(4):868-871.

Colburn TD, Holdsworth CT, Craig JC, Hirai DM, Montgomery S, Poole DC, Musch TI, Kenney MJ. ATPsensitive K+ channel inhibition via glibenclamide does not increase lumbar or renal sympathetic nerve discharge in healthy rats. Resp Physiol Neurobiol 2020; 278:103444.

Ferguson SK, Redinius KM, Harral JW, Pak DI, Hirai DM, Blackwell JR, Jones AM, Stenmark KR, Buehler PW, Irwin DC. Impact of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell anemia. J Appl Physiol 2020; 129(3):474-482.

Colburn TD, Hirai DM, Craig JC, Ferguson SK, Weber RK, Schulze K, Behnke BJ, Musch TI, Poole DC. Transcapillary PO2 gradients in contracting muscles across the fibre type and oxidative continuum. J Physiol 2020; 598(15):3187-3202.

Tabuchi A, Craig JC, Hirai DM, Colburn TD, Kano Y, Poole DC, Musch TI. Systemic NOS inhibition reduces contracting muscle oxygenation more in intact female than male rats. Nitric Oxide 2020; 100-101:38-44.

Neder JA, Rocha A, Arbex FF, Alencar MCN, Sperandio PA, Hirai DM, Berton DC, O'Donnell DE. Exertional oscillatory ventilation: a neglected cause of chronic unexplained dyspnea in subjects without heart failure. Int J Cardiol 2019 (submitted).

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