Faculty Associates

Daniel M. Hirai

Contact Information
Email: dhirai@purdue.edu
Office: LAMB 201C Map
Phone: (765)-494-7113
Fax: (765)-496-1239
Homepage: Homepage
Assistant Professor, Department of Health and Kinesiology

PubMed Listing
Google Scholar Listing

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PhD Kansas State University Physiology 2012

Research Interests

Exercise intolerance in heart failure patients, pharmacological and non-pharmacological interventions to improve skeletal muscle microvascular hemodynamics and oxygenation.

Teaching Interests

Exercise physiology, skeletal muscle, oxygen transport


2020 - Laboratory and University Core Facility Research Equipment Program, Office of the Executive Vice President for Research and Partnerships, Purdue University

Selected Publications

Hirai DM, Craig JC, Colburn TD, Eshima H, Kano Y, Musch TI, Poole DC. Skeletal muscle interstitial PO2 kinetics during recovery from contractions. J Appl Physiol 2019; 127(4): 930-939.

Craig JC, Colburn TD, Caldwell JT, Hirai DM, Tabuchi A, Baumfalk DR, Behnke BJ, Ade CJ, Musch TI, Poole DC. Central and peripheral factors mechanistically linked to exercise intolerance in heart failure with reduced ejection fraction. Am J Physiol Heart Circ Physiol 2019; 317:H434-H444.

Craig JC, Colburn TD, Hirai DM, Musch TI, Poole DC. Sexual dimorphism in the control of skeletal muscle interstitial PO2 of heart failure rats: effects of dietary nitrate supplementation. J Appl Physiol 2019; 126:1184-1192.

Bentley RF, Jones JH, Hirai DM, Zelt JT, Giles MD, Raleigh JP, Quadrilatero J, Gurd BJ, Neder JA, Tschakovsky ME. Submaximal exercise cardia outputs is increased by 4 weeks of sprint interval training in young healthy males with low initial Q-VO2: Importance of cardiac response phenotype. pLOS One 2019 Jan 23; 14(1): e0195458.

Zelt JT, Jones jH, Hirai DM, King tJ, Berton DC, Pyke KE, O'Donnell DE, Neder JA. Systemic vascular dysfunction is associated with emphysema burden in mild COPD. (2018) Respir Med 136:29-367.

Hirai DM, Copp SW, Ferguson SK, Holdsworth CT, Hageman KS, Poole DC, Musch TI. (2018) Neuronal nitric oxide synthase regulation of skeletal muscle functional hyperemia: exercise training and moderate compensated heart failure. Nitric Oxide 74:1-9.

Poole DC, Richardson RS, Haykowsky MJ, Hirai DM, Musch TI. (2018) Exercise limitations in heart failure with reduced and preserved ejection fraction. J Appl Physiol. 124:208-224.

Hirai DM, Jones jH, Zelt JT, da Silva ML, Bentley RF, Edgett BA, Gurd BJ, Tschakovsky ME, O'Donnell DE, Neder JA. (2017) Oral N-acetylcysteine and exercise tolerance in mild chronic obstructive pulmonary disease. J Appl Physiol. 122:1351-1361

Holdsworth CT, Ferguson SK, Colburn TD, Fees AJ, Craig JC, Hirai DM, Poole DC, Musch TI. (2017) Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure fats. Respir Physiol Neurobiol. 238:33-40.

Jones JH, Zelt JT, Hirai DM, Diniz CV, Zaza A, O'Donnell DE, Neder JA. (2017) Emphysema on Thoracic CT and Exercise Ventilatory Inefficiency in Mild-to-Moderate COPD. COPD 14:210-218.

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