Faculty Associates

David J. Waters

Contact Information
Email: dwaters@gpmcf.org
Phone: 765-775-1007
Homepage: Homepage
Director, Center for Exceptional Longevity Studies, Gerald P. Murphy Cancer Foundation

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PhD University of Minnesota 1992
DVM Cornell University 1984

Research Interests

  • Aging - Cancer Connection
  • Comparative Aspects of Biogerontology
  • Sex Differences in Biology & Medicine
  • U-Shaped Dose Responses & Health Promotion
  • Pet Dogs as a Model for Human Healthspan
  • Personalized Cancer Prevention
  • Cancer Resistance in Centenarians

Teaching Interests

  • Biology of Aging
  • Lifestyle & Age-Related Disease in the News
  • Tocandtocs: Skills & Attitudes of Personal Performance
  • Endocrinology of Aging
  • Cancer and Aging
  • Gerontology Training for DVMs


American Cancer Society
Brookdale Foundation
Department of Defense Prostate Cancer Research Program
National Academies - Keck Foundation Initiative
National Institutes of Health

Awards and Honors

1997 - Consultant, National Cancer Institute Prostate Cancer Progress Review Group to Formulate the Prostate Cancer Research Agenda of the U.S.
1999 - Brookdale National Fellowship for Leadership in Gerontology and Geriatrics
2005 - Great Teacher Award for Exceptional Interdisciplinary Teaching, Purdue University - Center on Aging and the Life Course
2007 - Invited Scientist, Department of Defense Prostate Cancer Research Program IMPACT (Innovative Minds in Prostate Cancer Today) - Top researchers of the decade
2007 - Invited Scientist, National Academies of Sciences - Keck Future Initiatives: "The Future of Human Healthspan"
2009 - Award for Research in Biological Mechanisms of Aging, Glenn Foundation for Medical Research

Selected Publications

Waters, D. J., & Wildasin, K. (2015). Cancer Clues from Pet Dogs. Scientific American, 24, 54-61.

Waters, D. J. (2014). Longevity in pet dogs: understanding what's missing. Veterinary journal (London, England: 1997), 200(1), 3.

Waters DJ. (2014). Longevity in pet dogs: Understanding what's missing. Vet J; 200-3-5.

Kengeri SS, Maras AH, Suckow CL, Chiang EC, Waters DJ. (2013). Exceptional longevity in female Rottweiler dogs is not encumbered by investment in reproduction. AGE; 35(6): 2503-2513.

Chiang EC, Bostwick DG, Waters DJ. (2013).Homeostatic housecleaning effect of selenium: Evidence that noncytotoxic oxidant-induced damage sensitizes prostrate cancer cells to organic selenium-triggered apoptosis. BioFactors; 39(5): 575-588.

Waters DJ. (2013). The paradox of tethering: Key to unleashing creative excellence in the research-education space. Informing Science; 15:229-245.

Waters DJ, Shen S, Kengeri SS, Chiang EC, Combs GF, Morris JS, Bostwick DG. (2012). Prostatic response to supranutritional selenium supplementation: Comparison of the target issue potency of selenomethionine vs. selenium-yeast on markers of prostatic homeostasis. Nutrients; 4:1650-1663.

Combs GF, Jackson MI, Watts JC, Johnson LK, Zeng H, Idso J, Schomburg L, Hoeg A, Hoefig C, Chiang EC, Waters DJ, Davis CD, Milner JA. (2012). Differential responses to selenomethionine supplementation by sex and genotype in health adults. Br J Nutr; 107: 1514-1525.

Waters DJ. Aging research (2011): exploring the pet dog paradigm. ILAR Journal; 52(1): 97-105.

Waters DJ, Waters LS. (2011). On the self-renewal of teachers. J Vet Med Educ; 38(3): 235-241.

Chiang EC, Shen S, Kengeri SS, Xu H, Combs GF Jr., Morris SJ, Bostwick DG, Waters DJ. (2010). Defining the optimal selenium dose for prostate cancer risk reduction: insights from the U-shaped relationship between selenium status, DNA damage, and apoptosis. Dose Response; 8: 285-300.

Rayman MP, Combs GF Jr, Waters DJ. (2009). Selenium and vitamin E supplementation for cancer prevention. JAMA; 301: 1876.

Waters DJ, Kengeri SS, Clever B, Booth JA, Maras AH, Schlittler DL, Hayek MG. (2009). Exploring mechanisms of sex differences in longevity: lifetime ovary exposure and exceptional longevity in dogs. Aging Cell; 8: 752-55.

Waters DJ, Chiang EC, Bostwick DG. (2008). The art of casting nets: fishing for the prize of personalized cancer prevention. Nutr Cancer; 60: 1-6.

Waters DJ, Shen S, Xu H, Kengeri SS, Cooley DM, Chiang EC, Chen Y, Schlittler D, Oteham C, Combs GF Jr, Glickman LT, Morris JS, Bostwick DG. (2007). Noninvasive prediction of prostatic DNA damage by oxidative stress challenge of peripheral blood lymphocytes. Cancer Epidemiol Biomarkers Prev; 16: 1906-1910.

Waters DJ, Wildasin K. (2006). Cancer clues from pet dogs. Scientific American; 295: 94-101.

Waters DJ, Shen S, Glickman LT, Cooley DM, Bostwick DG, Qian J, Combs GF Jr, Morris JS. (2005). Prostate cancer risk and DNA damage: translational significance of selenium supplementation in a canine model. Carcinogenesis; 26: 1256-1262.

Bostwick DG, Burke HB, Djakiew D, Euling S, Ho SM, Landolph J, Morrison H, Sonawane B, Shifflett T, Waters DJ, Timms B. (2004). Human prostate cancer risk factors. Cancer; 101(10 Suppl): 2371-2490.

Waters DJ, Chiang EC, Cooley DM, Morris JS. (2004). Making sense of sex and supplements: differences in the anticarcinogenic effects of selenium in men and women. Mutation Res; 551: 91-107.

Cooley DM, Schlittler DL, Glickman LT, Hayek M, Waters DJ. (2003). Exceptional longevity in pet dogs is accompanied by cancer resistance and delayed onset of major diseases. J Gerontol Biol Sci 58: B1078-1084.

Waters DJ, Shen S, Cooley DM, Bostwick DG, Qian J, Combs GF Jr, Glickman LT, Oteham C, Schlittler DL, Morris JS. (2003). Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate. J Natl Cancer Inst. 95: 237-241.

Waters DJ, Shen S, Glickman LT. (2000). Life expectancy, antagonistic pleiotropy, and the testis of dogs and men. Prostate; 43: 272-277.

Patronek GJ, Waters DJ, Glickman LT. ( 1997). Comparative longevity of pet dogs and humans: implications for gerontology research. J Gerontol 52A: B171-B178.

Waters DJ, Patronek GJ, Bostwick DG, Glickman LT. (1996).Comparing the age at prostate cancer diagnosis in human and dogs. J Natl Cancer Inst; 88: 1686-1687.

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