Faculty Associates

Wei Zheng

Contact Information
Email: wz18@purdue.edu
Office: CIVL 1169A Map
Phone: (765) 496-6447
Fax: (765) 496-1377
Homepage: Homepage
Head, School of Health Sciences, College of Health and Human Sciences
Professor of Health Sciences and Toxicology

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Education


PhD University of Arizona Pharmacology & Toxicology 1991

Research Interests


Toxicology of blood-brain barrier and blood-CSF barrier. Neurotoxicology of heavy metals (lead, manganese, iron, aluminum, and mercury): transport, homeostasis in the CNS, and molecular mechanisms. Roles of brain barriers in etiology of neurodegenerative diseases such as Parkinson's syndrome and Alzheimer's disease. Chelation therapy of metal toxicities. Transport of substances by the blood-CSF barrier in the choroid plexus. In vitro model of blood-brain/CSF barrier.

Teaching Interests


HSCI 101 Introduction to the Health Sciences Professions

Grants


2020 - National Institutes of Health/National Institute of Environmental Health Sciences (3)
2017 - Centers for Disease Control/National Institute for Occupational Safety and Health
2017 - National Institutes of Health/National Institute of Environmental Health Sciences
2016 - National Institutes of Health/National Institute of Neurological Disorders and Stroke
Ongoing - Johnson & Johnson Corp.

Selected Publications


Chen HH, Li XL, Ma H, Zheng W, and Shen XL, (2021). Reduction in nesfatin-1 levels in the cerebrospinal fluid and increased nigrostriatal degeneration following ventricular administration of anti-nesfatin-1 antibody in mice. Front. Neurosci. 15:621173 IF:3.707. doi: 10.3389/fnins.2021.621173

Zheng W and Ghersi-Egea, JF (2020). Brain barrier systems play no small roles in toxicant-induced brain diseases and disorders. Toxicol Sci 175(2):147-148. IF:4.081 (PMCID: PMC7253204).

Zheng W (2020). Systemic impact of trace elements on human health and disease: Nutrition, toxicity, and beyond (Editorial). J Trace Elem Med Biol 62:126634. IF:3.245. (PMCID: PMC7781149)

Shen XL, Xia L, Liu L, Jiang W, Shannahan J, Du Y, and Zheng W (2020). Altered clearance of beta-amyloid from the cerebrospinal fluid following subchronic lead exposure in rats: Roles of RAGE and LRP1 in the choroid plexus. J Trace Elem Med Biol 61: 126520. (PMCID: PMC7541561).

Li XL, Zhan RQ, Zheng W, Jiang H, Zhang DF, and Shen XL, (2020). Positive association between soil arsenic concentration and mortality from Alzheimer’s disease in mainland China. J Trace Elem Med Biol 59:126452. DOI: 10.1016/j.jtemb.2020.126452. (PMCID: PMC7350902)

Ding HW, Wang F, Su LY, Zhao L, Hu BL, Zheng W, Yao ST, and Li Y (2020). Involvement of MEK5/ERK5 signaling pathway in manganese-induced cell injury in dopaminergic MN9D cells. J Trace Elem Med Biol 61:126546. (DOI: 10.1016/j.jtemb.2020.126546. PMID: 32480051)

Hasan Z, Rolle-McFarland D, Liu Y, Zhou JQ, Mostafaei F, Li Y, Fan QY, Zhou YZ, Zheng W, Nie LH, and Wells EM (2020). Characterization of bone aluminum, a potential biomarker of cumulative exposure, within an occupational population from Zunyi, China. J Trace Elem Med Biol 59:126469 (PMCID: PMC7112220)

Gu HY, Territo PR, Persohn SA, Bedwell MM, Eldridge K, Speedy R, Chen Z, Zheng W and Du YS (2020). Evaluation of chronic lead effects in the blood brain barrier system by DCE-CT. J Trace Elem Med Biol 62:126648. (PMCID:PMC7655551)

Du XQ, Zheng W, and Ye Q (2020). Comparison of a rare case of severe life-threatening lead poisoning due to accidental exposure with a case of chronic lead poisoning due to occupational exposure. Toxicol Ind Health 36(12):951-959. (PMCID:PMC7752850)

Louis ED, Eliasen EH, Ferrer M, Hernandez DI, Gaini S, Jiang W, Zheng W, Nielsen F, and Petersen MS (2020). Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) and mercury in essential tremor: A population-based, environmental epidemiology study in the Faroe Islands. Neuroepidemiology 54:272-280. IF:2.558. (PMCID: PMC7210050)

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