Faculty Associates

Wei Zheng

Contact Information
Email: wz18@purdue.edu
Office: CIVL 1169A Map
Phone: (765) 496-6447
Fax: (765) 496-1377
Homepage: Homepage
Head, School of Health Sciences, College of Health and Human Sciences
Professor of Health Sciences and Toxicology

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M.S. Zhejiang University College of Pharmacy, Hangzhou, Pharmacology
Ph.D. University of Arizona, Tucson, AZ Pharmacology & Toxicology

Research Interests

Toxicology of blood-brain barrier and blood-CSF barrier. Neurotoxicology of heavy metals (lead, manganese, iron, aluminum, and mercury): transport, homeostasis in the CNS, and molecular mechanisms. Roles of brain barriers in etiology of neurodegenerative diseases such as ParkinsonĀŒs syndrome and AlzheimerĀŒs disease. Chelation therapy of metal toxicities. Transport of substances by the blood-CSF barrier in the choroid plexus. In vitro model of blood-brain/CSF barrier.

Teaching Interests

HSCI 101 Introduction to the Health Sciences Professions


National Institutes of Health-National Institute of Environmental Health Sciences
National Institutes of Health-National Institute of Neurological Disorders and Stroke
U.S. Department of Defense

Selected Publications

Fu S, Jiang W, Gao X, Zeng A, Cholger D, Cannon J, Chen J, and Zheng W* (2016), Aberrant adult Neurogenesis in the subventricular zone-rostral migratory stream-olfactory bulb system following subchronic manganese exposure. Toxicol Sci (in press) doi:10.1093/toxsci/kfw007

Hargrave SL, Davidson TL, Zheng W, and Kinzig KP (2016). Western diets induce blood-brain barrier leakage and alter spatial strategies in rats. Behavioral Neurosci 130(1):123-135. IF:2.728. PMID: 26595878

Liu XX, Walimbe T, Zheng W, and Sivasankar MP (2016). Acute single-walled carbon nanotube exposure on vocal fold epithelium. Annals of Otology, Rhinology and Laryngology (submitted)

O'Neal S and Zheng W* (2015). Manganese toxicity upon overexposure: A decade in review. Current Environmental Health Reports 2:315-328. (PMCID: PMC4545267)

Fu X, O'Neal S, Hong L, Jiang W and Zheng W* (2015). Elevated adult neurogenesis in brain subventricular zone following in vivo manganese exposure: Roles of copper and DMT1. Toxicol Sci 143(2):482-498. IF:3.845 (doi:10.1093/toxsci/kfu249) (PMCID: PMC4306725)

Zhang Longlian, Lu L, Pan YJ, Ding CG, Xu DY, Huang CF, Pan XF and Zheng W* (2015). Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb. Environ Res 140:10-17. IF:4.033 (PMCID: PMC4492836)

Bates CA, Fu S, Ysselstein D, Rochet JC and Zheng W* (2015). Expression and transport of a-synuclein at the blood-cerebrospinal fluid barrier and effects of manganese exposure. ADMET & DMPK 3(1):15-33. (PMCID: PMC4669215)

Fu S, Jiang W, and Zheng W* (2015). Age-dependent increase of brain copper levels and expressions of copper regulatory proteins in the subventricular zone and choroid plexus. Frontiers Mol Neurosci 8:22. IF:4.1 (PMCID: PMC4458609)

Fu X, Zhang YS, Jiang W, Monnot AD, Bates CA, and Zheng W* (2014). Regulation of copper transport crossing brain barrier systems by Cu-ATPases: Effect of manganese exposure. Toxicol Sci 139:432-451. (PMCID: PMC4064014)

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