Faculty Associates

Wei Zheng

Contact Information
Email: wz18@purdue.edu
Office: CIVL 1169A Map
Phone: (765) 496-6447
Fax: (765) 496-1377
Homepage: Homepage
Head, School of Health Sciences, College of Health and Human Sciences
Professor of Health Sciences and Toxicology

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Education


M.S. Zhejiang University College of Pharmacy, Hangzhou, Pharmacology
Ph.D. University of Arizona, Tucson, AZ Pharmacology & Toxicology

Research Interests


Toxicology of blood-brain barrier and blood-CSF barrier. Neurotoxicology of heavy metals (lead, manganese, iron, aluminum, and mercury): transport, homeostasis in the CNS, and molecular mechanisms. Roles of brain barriers in etiology of neurodegenerative diseases such as ParkinsonŒs syndrome and AlzheimerŒs disease. Chelation therapy of metal toxicities. Transport of substances by the blood-CSF barrier in the choroid plexus. In vitro model of blood-brain/CSF barrier.

Teaching Interests


HSCI 101 Introduction to the Health Sciences Professions

Grants


National Institutes of Health-National Institute of Environmental Health Sciences
National Institutes of Health-National Institute of Neurological Disorders and Stroke
U.S. Department of Defense

Selected Publications


Fu S, Jiang W, Gao X, Zeng A, Cholger D, Cannon J, Chen J, and Zheng W* (2016), Aberrant adult Neurogenesis in the subventricular zone-rostral migratory stream-olfactory bulb system following subchronic manganese exposure. Toxicol Sci (in press) doi:10.1093/toxsci/kfw007

Hargrave SL, Davidson TL, Zheng W, and Kinzig KP (2016). Western diets induce blood-brain barrier leakage and alter spatial strategies in rats. Behavioral Neurosci 130(1):123-135. IF:2.728. PMID: 26595878

Wang YF, Specht A, Liu YZ, Finney L, Maxey E, Zheng W, Weisskopf M, and Nie LH (2016). Micro-distribution of lead in human teeth using synchrotron-ģXRF. X-ray Spectrometry (to be submitted)

Liu XX, Walimbe T, Zheng W, and Sivasankar MP (2016). Acute single-walled carbon nanotube exposure on vocal fold epithelium. Annals of Otology, Rhinology and Laryngology (submitted)

O'Neal S and Zheng W* (2015). Manganese toxicity upon overexposure: A decade in review. Current Environmental Health Reports 2:315-328. (PMCID: PMC4545267)

Fu X, O'Neal S, Hong L, Jiang W and Zheng W* (2015). Elevated adult neurogenesis in brain subventricular zone following in vivo manganese exposure: Roles of copper and DMT1. Toxicol Sci 143(2):482-498. IF:3.845 (doi:10.1093/toxsci/kfu249) (PMCID: PMC4306725)

Zhang Longlian, Lu L, Pan YJ, Ding CG, Xu DY, Huang CF, Pan XF and Zheng W* (2015). Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb. Environ Res 140:10-17. IF:4.033 (PMCID: PMC4492836)

Bates CA, Fu S, Ysselstein D, Rochet JC and Zheng W* (2015). Expression and transport of a-synuclein at the blood-cerebrospinal fluid barrier and effects of manganese exposure. ADMET & DMPK 3(1):15-33. (PMCID: PMC4669215)

Fu S, Jiang W, and Zheng W* (2015). Age-dependent increase of brain copper levels and expressions of copper regulatory proteins in the subventricular zone and choroid plexus. Frontiers Mol Neurosci 8:22. IF:4.1 (PMCID: PMC4458609)

Fu X, Zhang YS, Jiang W, Monnot AD, Bates CA, and Zheng W* (2014). Regulation of copper transport crossing brain barrier systems by Cu-ATPases: Effect of manganese exposure. Toxicol Sci 139:432-451. (PMCID: PMC4064014)

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