M.S. Zhejiang University College of Pharmacy, Hangzhou, Pharmacology
Ph.D. University of Arizona, Tucson, AZ Pharmacology & Toxicology
Toxicology of blood-brain barrier and blood-CSF barrier.
Neurotoxicology of heavy metals (lead, manganese, iron, aluminum, and mercury): transport, homeostasis in the CNS, and molecular mechanisms.
Roles of brain barriers in etiology of neurodegenerative diseases such as ParkinsonĀŒs syndrome and AlzheimerĀŒs disease.
Chelation therapy of metal toxicities.
Transport of substances by the blood-CSF barrier in the choroid plexus.
In vitro model of blood-brain/CSF barrier.
HSCI 101 Introduction to the Health Sciences Professions
National Institutes of Health-National Institute of Environmental Health Sciences
National Institutes of Health-National Institute of Neurological Disorders and Stroke
U.S. Department of Defense
Fu S, Jiang W, Gao X, Zeng A, Cholger D, Cannon J, Chen J, and Zheng
W* (2016), Aberrant adult Neurogenesis in the subventricular zone-rostral migratory stream-olfactory bulb system following subchronic manganese exposure. Toxicol Sci
(in press) doi:10.1093/toxsci/kfw007
Hargrave SL, Davidson TL, Zheng
W, and Kinzig KP (2016). Western diets induce blood-brain barrier leakage and alter spatial strategies in rats. Behavioral Neurosci
130(1):123-135. IF:2.728. PMID: 26595878
Liu XX, Walimbe T, Zheng
W, and Sivasankar MP (2016). Acute single-walled carbon nanotube exposure on vocal fold epithelium. Annals of Otology, Rhinology and Laryngology (submitted)
O'Neal S and Zheng W* (2015). Manganese toxicity upon overexposure: A decade in review. Current Environmental Health Reports
2:315-328. (PMCID: PMC4545267)
Fu X, O'Neal S, Hong L, Jiang W and Zheng W* (2015). Elevated adult neurogenesis in brain subventricular zone following in vivo manganese exposure: Roles of copper and DMT1. Toxicol Sci
143(2):482-498. IF:3.845 (doi:10.1093/toxsci/kfu249) (PMCID: PMC4306725)
Zhang Longlian, Lu L, Pan YJ, Ding CG, Xu DY, Huang CF, Pan XF and Zheng W* (2015). Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb. Environ Res
140:10-17. IF:4.033 (PMCID: PMC4492836)
Bates CA, Fu S, Ysselstein D, Rochet JC and Zheng W* (2015). Expression and transport of a-synuclein at the blood-cerebrospinal fluid barrier and effects of manganese exposure. ADMET & DMPK
3(1):15-33. (PMCID: PMC4669215)
Fu S, Jiang W, and Zheng W* (2015). Age-dependent increase of brain copper levels and expressions of copper regulatory proteins in the subventricular zone and choroid plexus. Frontiers Mol Neurosci
8:22. IF:4.1 (PMCID: PMC4458609)
Fu X, Zhang YS, Jiang W, Monnot AD, Bates CA, and Zheng
W* (2014). Regulation of copper transport crossing brain barrier systems by Cu-ATPases: Effect of manganese exposure. Toxicol Sci
139:432-451. (PMCID: PMC4064014)
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