GCL.5.1

Overview: 

Several new scaffolds for targeting Myeloid-derived suppressor cells in cancer microenvironments alleviating immune supression. Mouse and Dog clinical studies have been conducted.

Stage: 

Purdue Faculty: 

Dr. Gaurav Chopra

Research Article: 

Cell-specific gene program-based small-molecule immunomodulators targeting solid-tumor microenvironments

Chemical screening based machine learning platform to identify MDSC-specific gene programs and immunomodulators to target solid tumor microenvironments