PSMA617-miR-34a
Overview:
Prostate-specific membrane antigen (PSMA)-targeted miRNA with the ability to escape the endosome to treat prostate cancer. Current lead molecule from the PSMA617-mIR platform.
Status:
Purdue Faculty:
Development Partner:
Research Articles:
Enhancing microRNA activity through increased endosomal release mediated by nigericin
New mechanism for release of endosomal contents: osmotic lysis via nigericin-mediated K+/H+ exchange