Purdue Institute for Drug Discovery

CCG258208

Overview: 

A selective small molecules based upon a paroxetine to selectively inhibit G Protein-Coupled Receptor Kinase 2 (GRK2) for the treatment of heart failure.

 

Status: 

Purdue Faculty: 

Dr. John Tesmer

Research Articles: 

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine