Purdue Institute for Drug Discovery

CB101

Overview: 

Small molecule DJ-1 targeting chaperone for the treatment of Parkinson's Disease

Status: 

Purdue Faculty: 

Dr. Chris Rochet

Development Partner: 

CantaBio Pharmaceuticals

Research Articles: 

Destabilization of DJ-1 by Familial Substitution and Oxidative Modifications:  Implications for Parkinson's Disease

Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease