Multiple proteinaceous alphavirus receptors have been discovered in recent years, including mammalian Mxra8, used by chikungunya and other members of the Semliki Forest virus family; avian Mxra8, used by the Western equine encephalitis virus family; LDLRAD3, used specifically by Venezuelan equine encephalitis virus; and VLDLR, used by Eastern equine encephalitis and select Semliki Forest family viruses. In this presentation we will explore the structural basis of these alphavirus/receptor interactions as well discuss the development of decoy receptors capable of neutralizing infections.