Current Projects

We are building a web platform that provides a full spectrum of data services, connects data to computational resources and statistical software, and tracks research workflows to link data, algorithms and results.

Post-Doctoral Researcher: Wes Flynn
Funding: The National Science Foundation Award # 1724728
PI: Ann Christine Catlin

Digital Environment for Enabling Data-Driven Science (DEEDS)
We are evaluating the organ distribution of nanoplastics in zebrafish.PhD Student: Rui Zhang
Funding: China Scholarship Council and Department of Forestry and Natural Resources, Purdue University
Toxicology of Nanoplastics
Using high throughput sequencing tools, we are identifying: 1) conserved patterns of response to oil across multiple species; 2) subtle effects resulting from exposure to oil that may have implications for future fisheries management practices, and; 3) novel hypotheses regarding the effects of oil on ecologically important fish species in the Gulf of Mexico.MS Student: Maggie Wigren
PhD Student: Elizabeth Allmon
Funding: Gulf of Mexico Research Initiative RFP VI
PI: Robert J Griffitt
Integrating Teleost Transcriptomes to Identify Ecologically meaningful Responses Following Oil Exposure
The objectives of this work are several-fold: 1) Develop toxicity reference values for PFAS in amphibians; 2) Decipher the mechanisms of toxicity of PFAS using several in vitro and in vivo models; and 3) Evaluate the effects of mixtures.PhD Student: Edgar Perez
MS Students: Ashley Newton and Evelyn Barragan
Per- and Polyfluoralkyl Substances (PFAS)
Using a combination of toxicity tests coupled with next generation sequencing tools, we are studying whether sea lampreys have developed resistance to TFM which has been used to control lampreys in the Great Lakes for over 65 years.Funding: Great Lakes Fishery Commission
PI: Mark Christie
Chemical Resistance of Sea Lampreys to TFM


Past Projects

We evaluated how temperature influences sex differentiation in fathead minnows. We induced non-directional sex reversal after exposing embryos and larvae from 0 h post fertilization to 45 days post hatch to fluctuating temperatures. Expression of hsp70 cycled with temperature.

Student: David Coulter(PhD) (was co-advised with Tomas Höök)
Funding: Electric Power Research Institute (EPRI)

Temperature and Sex Differentiation in Fathead Minnows
The objective of this study was to determine the prevalence of diseases (virus, bacteria, and helminths) from exotic silver and bighead carps from the Wabash River, IN.

Student: Kensey Thurner
Funding: Indiana Department of Natural Resources (IDNR)

Fish Diseases
We quantified PPCPs at the Baca Wildlife Refuge, CO and evaluated their impact to native fish such as the Rio Grande chub. We also conducted laboratory experiments with fathead minnows and examined mechanisms of toxicity of DEET, triclocarban, cotinine, and complex mixtures.

MS Student: Jenny Zenobio
Funding: United States Fish and Wildlife Service (USFWS) and Illinois-Indiana Sea Grant

Pharmaceuticals and Personal Care Products (PPCPs)
We have identified and validated a set of miRNAs from D. pulex that are responsive to heavy metal exposure.

PhD Student: Shuai Chen (co-advised by Krista Nichols)
Funding: Department of Forestry and Natural Resources, Purdue University

Function of miRNAs in Daphnia pulex
The objective of these studies was to assess the mechanism of vascular toxicity of nanosilver.

PhD Student: Jiejun Gao
Funding: China Scholarship Council and Department of Forestry and Natural Resources, Purdue University

Toxicology of Nanosilver
Using the zebrafish, we evaluated how a developmental exposure to atrazine results in later-in-life effects.

Funding: National Institute of Environmental Health Sciences
PI: Jennifer Freeman

Epigenetic Mechanisms of Atrazine
We evaluated the combined effects of extreme dissolved oxygen, temperature, salinity and oil on growth and survival of Fundulus grandis.

MS Students: Jennifer Serafin and Christopher Klinkhammer
Funding: Gulf of Mexico Research Initiative

Combined Effects of Abiotic Stressors and Oil Contaminants
We developed a transgenic Japanese Medaka model for detecting estrogens and anti-estrogens in water.

PhD Student: Ahmed Abdel-Moneim
Funding: Egyptian Government and Department of Forestry and Natural Resources, Purdue University

Molecular Markers of Gonadal Development and Intersex