Faculty Associates

Uma Aryal

Contact Information
Email: uaryal@purdue.edu
Office: BIND 216 Map
Phone: 765-494-4960
Homepage: Homepage
Research Associate Professor of Comparative Pathobiology
Director, Proteomics Facility

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Pillars of Interdisciplinary Research Excellence

Engineering over the Life Course


PhD Kyushu University of Japan 2006

Research Interests

Proteomics, cellular senescence, aging, diet-induced obesity

Teaching Interests

Proteomics applications in cell biology and beyond


2022 - CTSI Purdue Project Development Team Grant
2022 - Purdue PIIN/CEREBBRAL Grant
2021 - Purdue AgSeed
2021 - National Institutes of Health
2021 - Michael J. Fox Foundation
2021 - National Institute of Food and Agriculture
2021 - IADRC, Indiana University School of Medicine
2021 - Purdue EVPRP COVID Disruption Funding
2020 - National Science Foundation (two grants)
2020 - US Department of Veteran Affairs
2020 - Ralph W. and Grace Showalter Trust Award
2020 - NASA

Selected Publications

Kim, S.Q., Mohallem, R., Franco, J., Buhman, K.E., Kim, K.-H. and Aryal, U.K. (2022). Global landscape of protein complexes in postprandial-state livers from diet-induced obese and lean mice. Biochemical and Biophysical Research Communication, 629, 40-46.

Kim, S.Q., Mohallem, R., Franco, J., Buhman, K.K., Kim, K.-H. and Aryal, U.K. (2022). Multi-omics approach reveals dysregulation of protein phosphorylation correlated with lipid metabolism in mouse non-alcoholic fatty liver. Cells, 11(7), 1172.

Li, K., Sun, X., Zha, R., Liu, S., Feng, Y., Sano, T., Aryal, U.K., Sudo, A., Li, B.Y. and Yokota, H. (2022). Counterintuitive production of tumor-suppressive secretomes from Oct4-and c-Myc-overexpressing tumor cells and MSCs. Theranostics, 12(7), 3084.

Sun, X., LI, K., Aryal, U.K., Li, B.-Y. and Yokota, H. (2022). PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9. Molecular Therapy-Oncolytics, 26, 360-371.

Zembroski, A.S., Buhman, K.K. and Aryal, U.K. (2021). Proteome and phosphoproteome characterization of liver from diet-induced obese mice in the postprandial response to dietary fat. Journal of Proteomics, 232, 104072.

Mohallem, R. and Aryal, U.K. (2021). Quantitative proteomics and phosphoproteomics reveal TNF-alpha mediated protein functions in hepatocytes. Molecules, 26 (18), 5472.

Liu, S., Sun, X., Li, K., Zha, R., Feng, Y., Sano, T., Dong, C., Liu, Y., Aryal, U.K., Sodo, A, Li, B.-Y. and Yokota, H. (2021). Generation of the tumor-suppressive secretome from tumor cells. Theranostics, 11 (17), 8517.

Mohallem, R. and Aryal U.K. (2020). Regulators of TNF-? mediated insulin resistance elucidated by quantitative proteomics. Scientific Reports, 10 (1), 1-15.

Chan, H., Bhide, K.P., Vaidyam, A., Hedrick, V., Sobreira, T.J.P., Sors, T.G., Grant, G.W., and Aryal, U.K. (2019). Proteomic analysis of 3T3-L1 adipocytes treated with insulin and TNF-?. Proteomes, 20, 7 (4), 35.

Howe, E.N., Burnette, M.D., Justice, M.E., Schnepp, P.M., Hedrick, V., Clancy, J.E., Guldner, I.H., Lamere, A.T., Li, J., Aryal, U.K., DSouza-Schorey, C., Zartman, J.J. and Zhang, S. (2020). Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth. Nature Communication, 11(1), 1-15.

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