Faculty Associates

James F. Markworth

Contact Information
Email: jmarkwor@purdue.edu
Office: CRTN 2054 Map
Phone: 765-494-4846
Fax: 765-494-9346
Homepage: Homepage
Assistant Professor of Animal Sciences

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PhD Deakin University Skeletal Muscle Physiology 2013

Research Interests

Muscle Biology, Inflammation/Immunology, Bioactive Lipid Mediators, Polyunsaturated Fatty Acids, Sarcopenia, Regenerative Medicine

Teaching Interests

Nutritional Biochemistry, Muscle Biology, Physiology, Exercise Physiology/Metabolism


2022 - National Institutes of Health
2022 - Showalter Trust Awards
2018 - Glenn Foundation

Selected Publications

Figueiredo VC, Roberts LA, Cameron-Smith D, Markworth JF. Editorial: Modulators Of Skeletal Muscle Hypertrophy: Mechanisms To Lifestyle Strategies. Frontiers In Physiology. 2022. March 22. Https://www.frontiersin.org/articles/10.3389/fphys.2022.893698/full.

Guzman SD, Judge J, Shigdar S, Paul TA, Davis CS, Macpherson PC, Markworth JF, Van Remmen H, Richardson A, McArdle A, Brooks SV. Removal Of P16INK4 Expressing Cells In Late Life Has Moderate Beneficial Effects On Skeletal Muscle Function In Male Mice. 2021. Frontiers In Aging. 2:821904.doi: 10.3389/fragi.2021.821904.

Bjrnsen T, Wernbom M, Paulsen G, Markworth JF, Berntsen S, D'Souza RF, Cameron-Smith D, Raastad T. High-frequency Blood Flow Restricted Resistance Exercise Results In Acute And Prolonged Cellular Stress More Pronounced In Type I Than In Type II Fibers. Journal Of Applied Physiology. 2021 Aug 1;131(2):643-660.

Larouche J, Mohiuddin M, Choi JJ, Ulintz PJ, Fraczek PM, Sabin K, Pitchiaya S, Kurpiers SJ, Castor-Macias J, Liu W, Hastings RL, Brown LA, Markworth JF, De Silva K, Levi BD, Merajver SD, Valdez G, Chakkalakal JV, Jang Y, Brooks SV, Aguilar CA (2021). Murine Muscle Stem Cell Response To Perturbations Of The Neuromuscular Junction Are Attenuated With Aging. Elife. 2021 Jul 29;10:e66749.

Markworth JF, Brown LA, Lim E, Castor-Macias JA, Larouche J, Macpherson PCD, Davis C, Aguilar CA, Maddipati KR, Brooks SV. Metabolipidomic Profiling Reveals An Age-related Deficiency Of Skeletal Muscle Pro-resolving Mediators That Contributes To Maladaptive Tissue Remodeling. Aging Cell. 2021 Jun;20(6):e13393.

Markworth JF, Sugg KB, Sarver DC, Maddipati KR, Brooks SV. Local Shifts In Inflammatory And Resolving Lipid Mediators In Response To Tendon Overuse. The FASEB Journal. 2021 Jun;35(6):e21655.

Zeng N, D'Souza RF, Macrae C, Figueiredo VC, Pileggi CA, Markworth JF, Merry TL, Cameron-Smith D, Mitchell CJ. Daily Protein Supplementation Attenuates Immobilisation-induced Blunting Of Postabsorptive Muscle MTORC1 Activation In Middle Age Men. American Journal Of Physiology: Cell Physiology. 2021 Apr 1;320(4):C591-C601.

Figueiredo V, Van Pelt D, D'Souza R, Zeng N, Markworth JF, Poppitt S, Lawrence M, Miller B, Peterson C, McCarthy J, Dupont-Versteegden E, Mitchell CJ, And Cameron-Smith D. Ribosome Biogenesis And Degradation Regulate Translational Capacity During Muscle Disuse And Reloading. Journal Of Cachexia, Sarcopenia And Muscle. 2021 Feb;12(1):130-143.

Ramme AJ, Darcy R, Rourke BJ, Davis C, Markworth JF, Junginger L, Maerz T, Brooks SV, Bedi A. Local And Systemic Effects Of Blood Flow Restriction Therapy In An Animal Model. The American Journal Of Sports Medicine. 2020 Nov;48(13):3245-3254.

Markworth JF, Brown LA, Lim E, Floyd C, Larouche J, Castor-Macias JA, Sugg KB, Sarver DC, Macpherson PC, Davis C, Aguilar CA, Maddipati KR, Brooks SV. Resolvin D1 Supports Skeletal Myofiber Regeneration Via Actions On Myeloid And Muscle Stem Cells. JCI Insight. 2020 Sep 17;5(18):e137713.

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