Faculty Associates

Jason R. Cannon

Contact Information
Email: cannonjr@purdue.edu
Office: HAMP 1271 Map
Phone: (765)-494-0794
Fax: (765)-496-1377
Homepage: Homepage
Associate Professor of Health Sciences and Toxicology

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Education


PhD University of Michigan, Ann Arbor Toxicology 2006

Research Interests


Neurodegeneration, Neurotoxicology, Parkinson's disease, Gene-therapy

Teaching Interests


Toxicology, Analytical Toxicology, Toxicologic Pathology

Grants


2020 - National Science Foundation
2020 - National Institute of Neurological Disorders and Stroke
2020 - National Institute on Aging
2019 - Purdue Office of the Executive Vice President for Research and Partnerships
2018 - National Institute on Aging, National Institute of Environmental Health Sciences
2018 - National Institute of Neurological Disorders and Stroke
2016 - National Institute of Environmental Health Sciences

Selected Publications


Syeda, T., and Cannon, J. R. (2021). Environmental exposures and the etiopathogenesis of Alzheimer's disease: The potential role of BACE1 as a critical neurotoxic target. J Biochem Mol Toxicol doi: 10.1002/jbt.22694, e22694.

Lawana, V., Um, S. Y., Foguth, R. M., and Cannon, J. R. (2020). Neuromelanin formation exacerbates HAA-induced mitochondrial toxicity and mitophagy impairments. Neurotoxicology 81, 147-160.

Foguth, R., Sepulveda, M. S., and Cannon, J. (2020). Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health. Toxics 8(2).

Foguth, R. M., Hoskins, T. D., Clark, G. C., Nelson, M., Flynn, R. W., de Perre, C., Hoverman, J. T., Lee, L. S., Sepulveda, M. S., and Cannon, J. R. (2020). Single and mixture per- and polyfluoroalkyl substances accumulate in developing Northern leopard frog brains and produce complex neurotransmission alterations. Neurotoxicol Teratol doi: 10.1016/j.ntt.2020.106907, 106907.

Syeda, T., Foguth, R. M., Llewellyn, E., and Cannon, J. R. (2020). PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer's disease. Toxicology 437, 152436.

Bentz, B. Z., Mahalingam, S. M., Ysselstein, D., Montenegro, P. C., Cannon, J. R., Rochet, J. C., Low, P. S., and Webb, K. J. (2020). Localization of fluorescent targets in deep tissue with expanded beam illumination for studies of cancer and the brain. IEEE Trans Med Imaging doi: 10.1109/TMI.2020.2972200.

Lawana, V., Um, S. Y., Rochet, J. C., Turesky, R. J., Shannahan, J. H., and Cannon, J. R. (2020). Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology 173(1), 171-188.

Sammi, S. R., Foguth, R. M., Nieves, C. S., De Perre, C., Wipf, P., McMurray, C. T., Lee, L. S., and Cannon, J. R. (2019). Perfluorooctane Sulfonate (PFOS) Produces Dopaminergic Neuropathology in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology 172(2), 417-434, 10.1093/toxsci/kfz191.

Patel, S. H., Yue, F., Saw, S. K., Foguth, R., Cannon, J. R., Shannahan, J. H., Kuang, S., Sabbaghi, A., and Carroll, C. C. (2019). Advanced Glycation End-Products Suppress Mitochondrial Function and Proliferative Capacity of Achilles Tendon-Derived Fibroblasts. Sci Rep 9(1), 12614, 10.1038/s41598-019-49062-8.

Foguth, R. M., Flynn, R. W., de Perre, C., Iacchetta, M., Lee, L. S., Sepulveda, M. S., and Cannon, J. R. (2019). Developmental exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) selectively decreases brain dopamine levels in Northern leopard frogs. Toxicology and applied pharmacology 377, 114623, 10.1016/j.taap.2019.114623.

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