Faculty Associates

Jason R. Cannon

Contact Information
Email: cannonjr@purdue.edu
Office: HAMP 1271 Map
Phone: (765)-494-0794
Fax: (765)-496-1377
Homepage: Homepage
Assistant Professor of Health Sciences and Toxicology

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Research Interests


Neurodegeneration, Neurotoxicology, Parkinson's disease, Gene-therapy

Teaching Interests


Toxicology, Analytical Toxicology, Toxicologic Pathology

Selected Publications


Fu, S., Jiang, W., Gao, X., Zeng, A., Cholger, D., Cannon, J., Chen, J., and Zheng, W. (2016). Aberrant Adult Neurogenesis in the Subventricular Zone-Rostral Migratory Stream-Olfactory Bulb System Following Subchronic Manganese Exposure. Toxicological sciences : an official journal of the Society of Toxicology 150(2), 347-368, 10.1093/toxsci/kfw007.

Dukes, A. A., Bai, Q., Van Laar, V. S., Zhou, Y., Ilin, V., David, C. N., Agim, Z. S., Bonkowsky, J. L., Cannon, J. R., Watkins, S. C., Croix, C. M., Burton, E. A., and Berman, S. B. (2016). Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP+ exposure. Neurobiol Dis 95, 238-249, 10.1016/j.nbd.2016.07.020.

Wise, J. P., Jr., and Cannon, J. (2016). From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models. Toxicological sciences : an official journal of the Society of Toxicology 153(2), 372-81, 10.1093/toxsci/kfw133.

Di Maio, R., Cannon, J. R., and Timothy Greenamyre, J. (2015). Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats. Neurobiol Dis 73C, 356-365, 10.1016/j.nbd.2014.10.018.

Lee, J. W., Tapias, V., Di Maio, R., Greenamyre, J. T., and Cannon, J. R. (2015). Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiology of aging 36(1), 505-18, 10.1016/j.neurobiolaging.2014.07.011.

Robison, G., Sullivan, B., Cannon, J. R., and Pushkar, Y. (2015). Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation. Metallomics : integrated biometal science 7(5), 748-55, 10.1039/c5mt00023h.

Wirbisky, S. E., Weber, G. J., Sepulveda, M. S., Xiao, C., Cannon, J. R., and Freeman, J. L. (2015). Developmental origins of neurotransmitter and transcriptome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Toxicology 333, 156-167, 10.1016/j.tox.2015.04.016.

Zharikov, A. D.1, Cannon, J. R.1, Tapias, V.1, Bai, Q., Horowitz, M. P., Shah, V., El Ayadi, A., Hastings, T. G., Greenamyre, J. T., and Burton, E. A. (2015). shRNA targeting alpha-synuclein prevents neurodegeneration in a Parkinson's disease model. The Journal of clinical investigation 125(7), 2721-35, 10.1172/JCI64502. 1. Joint 1st authors.

Agim, Z. S., and Cannon, J. R. (2015). Dietary factors in the etiology of Parkinson's disease. BioMed research international 2015, 672838, 10.1155/2015/672838.

Lee, J. W., and Cannon, J. R. (2015). LRRK2 mutations and neurotoxicant susceptibility. Experimental biology and medicine 240(6), 752-9, 10.1177/1535370215579162.

Cannon, J. R., Geghman, K. D., Tapias, V., Sew, T., Dail, M. K., Li, C. Greenamyre, J. T. (2013) Expression of human E46K-mutated alpha-synuclein in BAC-transgenic rats replicates early-state Parkinson's disease features and enhances vulnerability to mitochondrial impairment. Exp Neurol. 240, 44-56.

Milanese, C., Sager, J. J., Bai, Q., Farrell, T. C., Cannon, J. R., Greenamyre, J. T. and Burton, E. A. (2012). Hypokinesia and reduced dopamine levels in zebrafish lacking beta- and gamma1-synucleins. The Journal of biological chemistry 287(5), 2971-83, 10.1074/jbc.M111.308312.

Cannon, J. R. and Greenamyre, J. T. (2011). The role of environmental exposures in neurodegeneration and neurodegenerative diseases. Toxicol Sci 124(2), 225-50, 10.1093/toxsci/kfr239.

Cannon, J. R., Sew, T., Montero, L., Burton, E. A. and Greenamyre, J. T. (2011). Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra. Exp Neurol 228(1), 41-52, 10.1016/j.expneurol.2010.10.016

Cannon, J. R. and Greenamyre, J. T. (2010). Neurotoxic in vivo models of Parkinson's disease recent advances. Prog Brain Res 184, 17-33, 10.1016/S0079-6123(10)84002-6.

Drolet, R. E., Cannon, J. R., Montero, L. and Greenamyre, J. T. (2009). Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiology of disease 36(1), 96-102, 10.1016/j.nbd.2009.06.017.

Cannon, J. R., Tapias, V., Na, H. M., Honick, A. S., Drolet, R. E. and Greenamyre, J. T. (2009). A highly reproducible rotenone model of Parkinson's disease. Neurobiology of disease 34(2), 279-90.

Cannon, J. R., Hua, Y., Richardson, R. J., Xi, G., Keep, R. F. and Schallert, T. (2007). The effect of thrombin on a 6-hydroxydopamine model of Parkinson's disease depends on timing. Behav Brain Res 183(2), 161-8, 10.1016/j.bbr.2007.06.004.

Cannon, J. R., Keep, R. F., Hua, Y., Richardson, R. J., Schallert, T. and Xi, G. (2005). Thrombin preconditioning provides protection in a 6-hydroxydopamine Parkinson's disease model. Neurosci Lett 373(3), 189-94.

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