Faculty Associates

James C. Fleet

Contact Information
Email: fleet@purdue.edu
Office: STON G-1D Map
Phone: (765) 494-0302
Fax: (765) 494-0906
Homepage: Homepage
Distinguished Professor of Nutrition Science

PubMed Listing
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Education


B.S. Cornell University Animal Science 1981
M.S. University of Delaware Animal Nutrition 1984
Ph.D. Cornell University Nutritional Biochemistry 1988

Research Interests


Vitamin D, impact on calcium metabolism, prostate cancer, Regulation of mineral metabolism, Intestinal biology, Impact of aging on biological function

Teaching Interests


Presentation skills for Graduate students (FN695) Nutritional Biochemistry and Physiology I (FN590B) Nutrition and Genetics (FN special topics course)

Grants


National Institutes of Health
US Veterans Administration
US Department of Agriculture
Private industry and foundations

Selected Publications


Reyes-Fernandez, P., Fleet, J.C. (2016) Compensatory changes in calcium metabolism accompany the loss of vitamin D receptor (VDR) from the distal intestine and kidney of mice. J. Bone Min. Res. 31:143-151 (IF 6.82)

Fleet, J.C., Replogle, R.A., Reyes-Fernandez, P., Wang, L., Zhang, M., Clinkenbeard, E.L., White, K.E. (2016) Gene-by-diet interactions affect serum 1,25 dihydroxyvitamin D levels in male BXD recombinant inbred mice. Endocrinology 157:470 (IF 4.503)

Wang, F. Johnson, R.L., Snyder, P.W., DeSmet, M.L., Fleet, J.C. (2016) An inducible large-intestine-specific transgenic mouse model for colitis and colitis-induced colon cancer research. Digestive Diseases and Sciences 61:1069-79 (IF 2.613) Figure 6 used on issue cover.

Reyes-Fernandez, P.C., Replogle, R.A., Wang, L., Zhang, M., Fleet, J.C. (2016) Novel genetic loci control calcium absorption and femur bone mass as well as their response to low calcium intake in BXD recombinant inbred mice. J. Bone Min. Res. 31:994-1002 (IF 6.82)

DeWitt, M., Johnson, R.L., Snyder, P., Fleet, J.C. (2015) The effect of 1,25 dihydroxyvitamin D3 treatment on the mRNA levels of -catenin target genes in mice with colonic inactivation of both APC alleles. J. Steroid Biochem. Mol. Biol. 148:103-110. (IF 3.282)

Reyes-Fernandez, P., Fleet, J.C. (2015) Luminal glucose does not enhance active intestinal calcium absorption in mice: Evidence against a role for Cav1.3 as a mediator of calcium uptake during absorption. Nutrition Res. 35:1009-1015 (IF 2.62)

Wright, C., Weinheimer, E., Fleet, J.C., Peacock, M., and Campbell, W.W. (2015) The apparent relationship between plasma 25-hydroxyvitamin D and insulin resistance is largely attributable to central adiposity in overweight and obese adults. J. Nutr. 145:2683-2689 (IF 3.9)

Replogle, R.M, Li, Q., and Fleet, J.C. (2014) Adaptation of bone and calcium (Ca) metabolism to low dietary Ca intake is affected by genetic background in mice. J. Bone Min. Res. 29:657-665. (IF 6.59)

Byun, A. Hung, K.E., Fleet, J.C., Bronson, R.T., Mason, J.B., Garcia, P.E., Crott, J.W. (2014) Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of APC and activation of mutant Kras. Cancer Letters 347:191-195. (IF 4.54)

Park, C.Y., Lee, W., Fleet, J.C., Allen, M.R., McCabe, G.P., Walsh, D.M, Weaver, C.M. (2014) Calcium and vitamin D intake independently affect calcium metabolism and bone properties in a model of transition through estrogen deficiency. Osteoporosis International. 25:1905-1915. (IF 4.04)

Yin, L., Unger, E.L., Jellen, L.C., Earley, C.J., Allen, R.P., Tomaszequicz, A., Fleet, J.C., and Jones, B.C. (2012) Systems genetic analysis of multivariate response to iron deficiency in mice. Am. J. Physiol. 302:R1282-1296.

Cui, M. and Fleet, J.C. (2012) Villin-promoter mediated transgenic of TRPV6 increases intestinal calcium absorption in wild-type and VDR knockout mice. J. Bone Min. Res. 27:2097-2107.

Jiang, Y. and Fleet, J.C. (2012) Effect of phorbol 12-myristate 13-acetate activated signaling pathways on 1a,25 dihydroxyvitamin D3 (1,25(OH)2D3) regulated 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1) gene expression in Caco-2 cells. J. Cell. Biochem. 113:1599-1607.

Jiang, Y., Cui, M., and Fleet, J.C. (2012) Phorbol esters enhance 1a,25(OH)2D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (SP3) in Caco-2-cells. Mol. Cell Endocrinol. 361:31-39.

Farrow, E.G., Yu, X., Summers, L.J., Davis, S.I., Fleet, J.C., Allen, M.R., Robling, A.G., Stayrook, K.R., Jideonwon, V., Magers, M.J., Garringer, H.J., Vidal, R., Chan, R.J., Goodwin, C.B., Hui, S., Peacock, M., and White, K.E. (2011) Altered FGF23 proteolytic regulation causes late-onset hypophosphatemia during iron deficiency in an ADHR mouse model. Proc. Natl. Acad. Sci. USA. 108:E1146-1155.

Kovalenko, P.L., Zhang, Z., Yu, J.G., Clinton, S.K., and Fleet, J.C. (2011) Disrupting vitamin D (VD) signaling increases androgen dependent proliferation and reduces apoptosis in mouse prostate. Cancer Prevention Research.

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