Interdisciplinary Life Science - PULSe Great research is a matter of choice

Jennifer L. Freeman

Jennifer L. Freeman Profile Picture

Assistant Professor of Toxicology
Ph.D., Environmental Toxicology and Molecular Cytogenetics, University of Illinois at Urbana-Champaign


Contact Info:

jfreema@purdue.edu
765-494-1408


Training Group(s):
Molecular Signaling and Cancer Biology
Integrative Neuroscience


Current Research Interests:

Dr. Freeman's research efforts are focused on investigating the adverse effects of environmental stressors on human and environmental health using the zebrafish model system. Current research projects include (1) defining the influence of environmental stressors on genomic instability and carcinogenicity, (2) investigating the role of structural genetic variation in response to exposure to environmental stressors, and (3) identifying the role of environmental stressors in the onset of neurodegenerative disorders.



Selected Publications:

Zhang, J., S.M. Peterson, G.J. Weber, X. Zhu, W. Zheng, and J.L. Freeman. 2011. Decreased axonal density and altered expression profiles of axonal guidance genes underlying lead (Pb) neurodevelopmental toxicity at early embryonic stages in the zebrafish. Neurotox. Teratol. doi:10.1016/j.ntt.2011.07.010.

Peterson, S.M., J. Zhang, G.J. Weber, and J.L. Freeman. 2011. Global gene expression analysis reveals dynamic and developmental stage dependent enrichment of lead (Pb)-induced neurological gene alterations. Environ. Health Perspect. 119:615-621.

Peterson, S.M. and J.L. Freeman. 2009. Cancer cytogenetics in the zebrafish. Zebrafish. 6:355-360.

Peterson, S.M. and J.L. Freeman. 2009. RNA isolation from embryonic zebrafish and cDNA synthesis in preparation for gene expression analysis. J. Vis. Exp. 30, doi: 10.3791/1470.

Peterson, S.M. and J.L. Freeman. 2009. Global gene expression analysis using a zebrafish oligonucleotide microarray platform. J. Vis. Exp. 30, doi: 10.3791/1471.

Freeman, J.L., C. Ceol, H. Feng, D.M. Langenau, C. Belair, H.M. Stern, A. Song, B.H. Paw, A.T. Look, Y. Zhou, L.I. Zon, and C. Lee. 2009. Construction and application of a zebrafish array CGH platform. Genes Chromosomes Cancer 48:155-170.

Yoder, J.A., J.P. Cannon, R.T. Litman, C. Murphy, J.L. Freeman, and G.W. Litman. 2008. Evidence for a transposition event in a second NITR gene cluster in zebrafish. Immunogenetics 60:257-265.

Freeman, J.L., A. Adeniyi, R. Banerjee, S. Dallaire, S. F. Maguire, J. Chi, B.L. Ng, C. Zepeda, C.E. Scott, S. Humphray, J. Rogers, Y. Zhou, L.I. Zon, N.P. Carter, F. Yang, and C. Lee. 2007. Definition of the zebrafish genome using flow cytometry and cytogenetic mapping. BMC Genomics 8: 195.

Shepard, J.L., J.F. Amatruda, D. Finkelstein, J. Ziai, K.R. Finley, H.M. Stern, K. Chiang, C. Hersey, B. Barut, J.L. Freeman, C. Lee, J.N. Glickman, J.L. Kutok, J.C. Aster, and L.I. Zon. 2007. A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes Dev. 21:55-59.

Cho, E.K., J. Tchinda, J.L. Freeman, Y.J. Chung, W.W. Cai, and C. Lee. 2006. Array-based comparative genomic hybridization and copy number variation in cancer research. Cytogen. Gen. Res. 115:262-272.

Freeman, J.L., G.H. Perry, L. Feuk, R. Redon, S.A. McCarroll, D.M. Altshuler, H. Aburatani, K. Jones, C. Tyler-Smith, M.E. Hurles, N.P. Carter, S.W. Scherer, and C. Lee. 2006. Copy number variation: New insights in genome diversity. Genome Res. 16:949-961.

Redon, R., S. Ishikawa, K.R. Fitch, L. Feuk, G.H. Perry, T.D. Andrews, H. Fiegler, M.H. Shapero, A.R. Carson, W. Chen, E.K. Cho, S. Dallaire, J.L. Freeman, J.R. Gonzalez, M. Gratacos, J. Huang, D. Kalaitzopoulos, D. Komura, J.R. MacDonald, C.R. Marshall, R. Mei, L. Montgomery, K. Nishimura, K. Okamura, F. Shen, M.J. Somerville, J. Tchinda, A. Valsesia, C. Woodwark, F. Yang, J. Zhang, T. Zerjal, J. Zhang, L. Armengol, D.F. Conrad, X. Estivill, C. Tyler-Smith, N.P. Carter, H. Aburatani, C. Lee, K.W. Jones, S.W. Scherer, and M.E. Hurles. 2006. Global variation in copy number in the human genome. Nature 444:444-454.

Freeman, J.L. and A.L. Rayburn. 2005. Localization of repetitive DNA sequences on in vitro Xenopus laevis chromosomes by primed in situ labeling (PRINS). J. Hered. 96:603-606.

Freeman, J.L., N. Beccue, and A.L. Rayburn. 2005. Differential metamorphosis alters the endocrine response in anuran larvae exposed to T3 and atrazine. Aquat. Toxicol. 75:263-276.

Freeman, J.L. and A.L. Rayburn. 2004. In vivo genotoxicity of atrazine to anuran larvae. Mutat. Res. Gen. Tox. En. 560:69-78

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