Message from the Director

This year, the Center celebrates its 30th anniversary since it’s inception in 1987. Many brilliant scientists and engineers have come and gone but we remain steadfast in our mission to improve the quality of life for both animals and humans enduring neurologic deficits. We look forward to building on our rich history of translational excellence and are poised to take a leading role in the next breakthrough discovery.

  • Dr. Li receives two-year funding from CTSI to study the role of antigen based nanoparticles in spinal cord repair
  • We are seeking clinical collaborations for the new generation of spinal implants
  • Dr. Richard Borgens announces retirement
  • Alexander Lai presents at the Purdue Summer SURF conference 
  • The Center is featured on Jeopardy! (6/13/2017 episode)
  • Kavya Cherukuri presents at Neutrotrauma
  • OFS App for controlling OFS device published by Apple
Recent Publications
  1. Li J.Weak direct current (DC) electric fields as a therapy for spinal cord injuries: review and advancement of the oscillating field stimulator (OFS).Neurosurg Rev. 2019.
  2. Li J, Gao W.Fabrication and characterization of 3D microtubular collagen scaffolds for peripheral nerve repair.J Biomater Appl. 2018; 33(4):541-552.
  3. Chen B, Li J, Borgens RB. Neuroprotection by chitosan nanoparticles in oxidative stress-mediated injury. BMC Res Notes. 2018;11(1):49
  4. Li J. Biomaterial and Cell Interactions - the foreign body response as an obstacle in nanomedicine. J. Nanomedicine Res. 2017; 5(6).
  5. Li J, Chang JW, Saenger M, Deering A. Thymol nanoemulsions formed via spontaneous emulsification: physical and antimicrobial properties. Food Chem. 2017;232:191-197
  6. Gao W, Li J. Targeted siRNAs Delivery Reduces Nitric Oxide Mediated Cell Death After Spinal Cord Injury. J. Nanobiotechnology. 2017;15(1):38.
Spinal Cord Injury

Spinal Cord Injury

Each year, about 13,000 new cases of traumatic spinal cord injuries occur in the U.S. alone. The biologic and functional consequences of such injuries are often permanent and the financial, emotional and social impacts far reaching. The CPR seeks to understand the underlying pathophysiology of spinal cord damage and is also is engaged in translation research to repair, restore or regenerate damaged tissues through a variety of novel technologies.

Spinal Cord Injury Research: Overview
Brain Injury

Brain Injury

Traumatic brain injuries occur in many forms including stroke, acute head trauma, mild repetitive trauma (concussions). These modes of trauma can lead to neurodegeneration as well as functional and cognitive defects. The Center is investigating novel polymer based fusogens and molecular scavengers that exert neuroprotective effects to reduce the impact of secondary injury in nervous tissues.

Brain Injury: Overview
Nanotechnology & Peripheral Nerve

Nanotechnology & Peripheral Nerve

In addition to CNS injury, the Center is also involved in research to promote repair and regeneration of damaged peripheral nerve. Of special interest are developing biomaterial constructs/devices for enhancing the rate of axon regeneration. Further, the Center is engaged in various nanotechnology platforms for delivering therapeutic agents to target tissues. A focus area is in controlled release platforms and “smart” biomaterials.

Nanotechnology and Peripheral Nerve: Overview

Center for Paralysis Research:

The Center for Paralysis Research (CPR) is an interdiscplinary basic science and neuroengineering group located within the Purdue University College of Veterinary Medicine. The CPR has an unmatched record of moving basic research into clinical development, with three technologies having gone through FDA Phase 1 trials and one treatment already approved for multiple sclerosis patients. The Center investigates innovative ways to solve problems of the nervous system and welcomes ideas that challenge traditional dogma. 

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