SHP2 Inhibitors for Anti-Cancer Therapy
Overview:
Tyrosine phosphatase SHP2 inhibitors for the treatment of various cancers.
Status:
Purdue Faculty:
Development Partners:
Research Articles:
SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer
Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma
Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
Therapeutic Potential of Targeting Oncogenic SHP2 Phosphatase
SHP2 phosphate as a novel target for melanoma treatment
Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity